肺癌相关恶性胸腔积液预测模型的研究进展

Research progress on prediction model of malignant pleural effusion associated with lung cancer

恶性胸腔积液是一类异质性的疾病,通常为其他肿瘤转移至胸膜引起,属于恶性肿瘤终末状态。相对于其它部位的远处转移来说,恶性胸腔积液带给患者的痛苦和临床管理难度都更高,其中肺癌导致的恶性胸腔积液更加常见。如何为这些患者选择个性化的治疗方案是目前引起广泛关注和争议的问题。准确预测恶性胸腔积液患者的生存时间和预后可以为这些问题提供突破口。本文介绍了目前比较成熟且得到了广泛认可的几项恶性胸腔积液的预测模型,总结了一些普遍存在的问题,以期能为肺癌伴恶性胸腔积液的生存预测提供新思路。

Malignant pleural effusion is a heterogeneous disease,usually caused by metastasis of other tumors to the pleura,which belongs to the terminal state of malignant tumors.Compared with distant metastases from other sites,malignant pleural effusion brings more pain and difficulty in clinical management,and malignant pleural effusion caused by lung cancer is more common.How to choose personalized treatment for these patients is a problem that has attracted wide attention and controversy at present.Accurate prediction of the survival time and prognosis of patients with malignant pleural effusion can provide a breakthrough for these problems.In this paper,several mature and widely accepted prediction models of malignant pleural effusion are introduced,and some common problems are summarized,in order to provide new ideas for survival prediction of lung cancer with malignant pleural effusion.