格列美脲联合甘精胰岛素注射液治疗初诊2型糖尿病患者的疗效分析

Analysis on Efficacy of Glimepiride Combined with Insulin Glargine Injection in the Treatment of Patients with Newly Diagnosed Type 2 Diabetes Mellitus

目的:探究格列美脲联合甘精胰岛素注射液治疗初诊2型糖尿病的疗效。方法:选取我院2016年9月—2018年6月收治的初诊2型糖尿病患者82例,按随机数字表法分为对照组与观察组,各41例。对照组给予预混人胰岛素类似物治疗,观察组给予格列美脲、甘精胰岛素注射液联合治疗。比较两组疗效、低血糖发生率、胰岛素用量、动态血糖监测情况[平均血糖波动幅度(MAGE)、血糖达标时间、24 h平均血糖(MBG)]及治疗前后胰岛功能[抵抗指数(HOMA-IR)、分泌指数(HOMA-IS)]。结果:观察组总有效率高于对照组,差异有统计学意义(P<0.05);治疗后观察组HOMA-IR较对照组低,HOMA-IS较对照组高,差异有统计学意义(P<0.05);观察组MAGE较对照组低,MBG较对照组高,血糖达标时间较对照组短,差异有统计学意义(P<0.05);观察组低血糖发生率、胰岛素用量低于对照组,差异有统计学意义(P<0.05)。结论:格列美脲、甘精胰岛素注射液联合治疗初诊2型糖尿病的疗效显著,可减少胰岛素用量,促进血糖平稳达标,降低低血糖发生率,改善胰岛功能。

Objective:To explore the efficacy of glimepiride combined with insulin glargine injection in the treatment of patients with newly diagnosed type 2 diabetes mellitus.Method:82 patients with newly diagnosed type 2 diabetes mellitus admitted to our hospital from September 2016 to June 2018 were selected and randomly divided into a control group and an observation group,41 cases each.The patients in the control group were treated with premixed human insulin analogs,and the patients in the observation group were treated with glimepiride and insulin glargine injection.The efficacy,hypoglycemia incidence,insulin dosage,dynamic blood glucose monitoring[mean amplitude of glycemic excursion(MAGE),blood glucose compliance time,24 h mean blood glucose(MBG)],and islet function before and after treatment[insulin resistance index(HOMA-IR),secretion index(HOMA-IS)]were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the HOMA-IR in the observation group was lower than that in the control group,while the HOMA-IS was higher than that in the control group,with statistically significant differences(P<0.05).The MAGE in the observation group was lower than that in the control group,while the MBG was higher than that in the control group,and the blood glucose compliance time was shorter than that in the control group,with statistically significant differences(P<0.05).The hypoglycemia incidence and insulin dosage in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Glimepiride combined with insulin glargine injection has a significant therapeutic effect on newly diagnosed type 2 diabetes mellitus,which can reduce the insulin dosage,promote smooth blood glucose compliance,reduce the incidence of hypoglycemia and improve islet function.