摘要
目的:系统整理和评价健脾疏肝法治疗糖尿病前期患者的用药规律和临床疗效。方法:收集2021年3月之前公开发表的健脾疏肝法治疗糖尿病前期患者的临床研究文献,采用文献系统评价方法定量分析,探究中医药治疗糖尿病前期的临床疗效及用药规律。结果:经筛选后,最终纳入合格文献8篇,共治疗患者641例。对纳入的符合标准的8篇临床随机对照试验文献,采用SPSS21软件对其所用中药处方高频药物进行聚类分析,采用ReviewManager 5.3软件对其疗效进行Meta分析。结果显示,与对照组相比,对空腹血糖的影响[MD=-0.55,95%CI(-1.19,0.08)],餐后2小时血糖的影响[MD=-0.51,95%CI(-0.94,-0.08)],糖化血红蛋白的影响[MD=-0.37,95%CI(-1.07,0.33)],空腹C肽的影响[MD=0.29,95%CI(0.02,0.56)]。结论:聚类分析所得核心药物组合5组,以健脾燥湿、疏肝理气类药物为主。健脾疏肝法对降低糖尿病前期患者餐后2小时血糖具有较大的优势,但对降低空腹血糖、糖化血红蛋白以及空腹C肽作用不大。本研究所纳文献样本量较小,今后仍需要大样本、多中心随机对照试验来验证其疗效,为临床提供更大参考价值。
Objective:To systematize and evaluate the rule of medication and clinical efficacy of spleen-invigorating and liversoothing therapy on pre-diabetes.Methods:The clinical research literature on treating prediabetes patients with the method of invigorating the spleen and soothing the liver published before March 2021 was collected.Exploring the clinical efficacy and medication rules of TCM on pre-diabetes was quantitatively analyzed by the literature system evaluation method.Results:After screening,8 qualified literatures were finally included,in sum of 641 patients.SPSS 21 software was adopted in cluster analysis of high-frequency herbs of the traditional Chinese medicine prescription,and Review Manager 5.3 software was used for meta-analysis of the 8 included literatures of randomized controlled trials that met the standards.The results showed that,compared to the control group,glucose[MD=-0.55,95%CI(-1.19,0.08)],blood glucose 2 h after meal[MD=-0.51,95%CI(-0.94,-0.08)],glycated hemoglobin[MD=-0.37,95%CI(-1.07,0.33)],fasting C-peptide[MD=0.29,95%CI(0.02,0.56)].Conclusion:The core drug plus obtained by cluster analysis was 5 groups,mainly drugs of invigorating spleen and dampness,soothing liver and regulating Qi(气).The method of strengthening the spleen and soothing the liver has a great advantage in reducing blood glucose 2 hours after meal in pre-diabetic patients,but has little effect on reducing glucose,glycosylated hemoglobin and fasting C-peptide.This research has a small sample size of literature,and large samples and multi-center randomized controlled trials were still needed in the future to verify,its efficacy and provide greater clinical reference value.
出处
《中医临床研究》
2021年第34期121-125,共5页
Clinical Journal Of Chinese Medicine
关键词
糖尿病前期
健脾疏肝
META分析
Prediabetes
Invigorate the spleen and nourish the liver
Meta analysis