疏血通注射液联合艾地苯醌对脑梗死后血管性认知障碍患者脑血流灌注、神经电生理指标及Hcy的影响

Effects of Shuxuetong Injection(疏血通注射液)Combined with Idebenone on Cerebral Blood Flow Perfusion,Neuroelectrophysiological Indexes and Hcy in Patients with Vascular Cognitive Impairment after Cerebral Infarction

目的探讨疏血通注射液联合艾地苯醌对脑梗死后血管性认知障碍患者脑血流灌注、神经电生理指标及同型半胱氨酸(Hcy)的影响。方法选取诊治的脑梗死后血管性认知功能障碍患者80例,随机分为对照组与观察组,每组40例,对照组给予艾地苯醌口服治疗,观察组在对照组用药基础上联合疏血通注射液静脉滴注治疗,共治疗3个月,观察治疗前后两组脑血流灌注、神经电生理指标及血清Hcy变化,对治疗疗效进行评价。结果两组患者治疗前脑血流灌注指标(CBF)、脑血流平均通过时间(MTT)、脑血流容积(CBV)比较差异无统计学意义(P>0.05),治疗后CBF及CBV较治疗前明显升高,且观察组升高幅度大于对照组,MTT较治疗前明显下降,且观察组下降幅度大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前P300潜伏期及波幅、(δ+θ)/(α+β)比值比较差异无统计学意义(P>0.05),治疗后的P300潜伏期及(δ+θ)/(α+β)比值较治疗前明显下降,且观察组下降幅度大于对照组,P300波幅较治疗前明显升高,且观察组升高幅度大于对照组,比较差异有统计学意义(P<0.05);两组患者治疗前血清Hcy水平比较差异无统计学意义(P>0.05),治疗后Hcy水平较治疗前明显下降,且观察组下降幅度大于对照组,比较差异有统计学意义(P<0.05);观察组治疗总有效率为92.50%(37/40),高于对照组的75.00%(30/40),比较差异有统计学意义(P<0.05)。结论疏血通注射液联合艾地苯醌治疗脑梗死后血管性认知功能障碍能有助于进一步改善患者脑血流灌注及神经电生理功能,降低血清Hcy水平,改善患者认知功能,提高治疗疗效。

Objective To discuss the effects of Shuxuetong Injection(疏血通注射液)combined with idebenone on cerebral blood flow perfusion,neuroelectrophysiological indexes and homocysteine(Hcy)in patients with vascular cognitive impairment after cerebral infarction.Methods We collected 80 patients with vascular cognitive impairment after cerebral infarction were randomly divided into the control group and the observation group,40 cases in the each group.The control group was given oral treatment with idebenone and the observation group was combined with Shuxuetong Injection by intravenous infusion on the basis of control group.The treatment lasted for 3 months.The changes of cerebral blood perfusion,neuroelectrophysiological indexes and serum Hcy in the two groups before and after treatment were observed and the therapeutic efficacy was evaluated.Results There were no significant differences in cerebral blood flow perfusion index(CBF),mean time of cerebral blood flow(MTT)or cerebral blood flow volume(CBV)between the two groups before treatment(P>0.05).CBF and CBV were significantly higher after treatment than those before treatment.Those of the observation group were increased more than those of the control group.MTT was significantly lower than that before treatment,and that of the observation group was decreased more than that of the control group.The difference was statistically significant(P<0.05).There were no significant differences in P300 latency,amplitude or(δ+θ)/(α+β)between the two groups before treatment(P>0.05).The P300 incubation period and(δ+θ)/(α+β)ratio were significantly lower after treatment,and those of the observation group were decreased more than those of the control group.The P300 amplitude was significantly higher after treatment than that before treatment.The amplitude of the observation group was increased more than that of the control group and the difference was statistically significant(P<0.05).There were no significant differences in serum Hcy between the two groups before treatment(P>0.05).The serum Hcy was significantly lower than that before treatment,and the serum Hcy of the observation group was decreased more than that of the control group.The difference was statistically significant(P<0.05).The total effective rate of the observation group was 92.50%(37/40)and the control group was 75.00%(30/40).The difference was statistically significant(P<0.05).Conclusion Shuxuetong Injection combined with idebenone in the treatment of vascular cognitive impairment after cerebral infarction can help to further improve the patients'cerebral blood flow perfusion and neuroelectrophysiological function,reduce the level of serum Hcy and improve the patients'cognitive function and the therapeutic effect.