益气养血汤对气血亏虚型椎基底动脉系统短暂性脑缺血性眩晕中医证候、动脉血流及血液流变学的影响

Effects of Yiqi Yangxue Decoction(益气养血汤)on Traditional Chinese Medicine Symptoms,Arterial Blood Flow and Hemorheology of Vertebrobasilar Artery Transient Ischemic Attack Vertigo Patients with Qi and Blood Deficiency Syndrome

目的探讨益气养血汤对气血亏虚型椎基底动脉系统短暂性脑缺血性眩晕患者中医证候、动脉血流及血液流变学的影响。方法选取诊治的气血亏虚型VA-TIA眩晕患者100例,随机分为对照组与观察组,每组50例,对照组患者采用肠溶阿司匹林及氟桂利嗪口服治疗,观察组在以上用药基础上给予益气养血汤口服治疗,观察两组治疗前后中医证候积分变化,左侧椎动脉(LVA)、右侧椎动脉(RVA)、基底动脉(BA)的平均血流速度,血小板聚集率、全血还原黏度、血浆黏度及红细胞比容变化,采用眩晕障碍调查表(DHI)进行调查治疗前后眩晕程度。结果两组治疗前主症及次症症状证候积分比较差异无统计学意义(P>0.05),治疗后较治疗前积分下降(P<0.05),且观察组下降幅度大于对照组(P<0.05);两组患者治疗前LVA、RVA、BA的平均血流速度比较差异无统计学意义(P>0.05),治疗后较治疗前血流速度增高(P<0.05),且观察组高于对照组(P<0.05);两组患者治疗前后血小板聚集率、全血还原黏度、血浆黏度及红细胞比容比较差异无统计学意义(P>0.05),治疗后较治疗前以上指标水平均降低(P<0.05),且观察组低于对照组(P<0.05);两组患者治疗前DHI评分比较差异无统计学意义(P>0.05),治疗后较治疗前评分降低(P<0.05),且观察组低于对照组(P<0.05)。结论气养血汤治疗气血亏虚型VA-TIA眩晕能有助于改善症状,提高脑动脉血流速度,降低血液黏稠度改善血液流变学,效果显著。

Objective To investigate the effects of Yiqi Yangxue Decoction(益气养血汤)on traditional Chinese medicine symptoms,arterial blood flow and hemorheology of vertebrobasilar artery transient ischemic attack(VA-TIA)vertigo patients with Qi and blood deficiency syndrome.Methods A hundred cases of VA-TIA vertigo patients with Qi and blood deficiency syndrome were randomly divided into control group and observation group,50 cases in each group.The control group was treated with enteric-coated aspirin and flunarizine orally.The observation group was treated with Yiqi Yangxue Decoction orally on the basis of the above medication.We observed the average blood flow velocity,platelet aggregation rate,whole blood reduction viscosity,plasma viscosity and erythrocyte specific volume of left vertebral artery(LVA),right vertebral artery(RVA)and basilar artery(BA)of the two groups before and after treatment.Vertigo disorder questionnaire(DHI)was used to investigate the degree of vertigo before and after treatment.Results There was no statistically significant difference in scores of primary and secondary symptoms before treatment between the two groups(P>0.05),Scores were decreased after treatment compared with those before treatment(P<0.05),and the decrease amplitude in the observation group was greater than that in the control group(P<0.05).There was no statistically significant difference in the average flow velocity of LVA,RVA or BA between the two groups before treatment(P>0.05).The blood flow velocity was increased after treatment compared with that before treatment(P<0.05)and that of the observation group was higher than that of the control group(P<0.05).There was no statistically significant difference in platelet aggregation rate,whole blood reduction viscosity,plasma viscosity or erythrocyte specific volume before treatment between the two groups(P>0.05).The levels of the above indicators after treatment were lower than those before treatment(P<0.05),and the levels of the observation group were lower than those of the control group(P<0.05).There was no statistically significant difference in DHI scores between the two groups before treatment(P>0.05),and the scores after treatment were lower than those before treatment(P<0.05),and the observation group's scores were lower than those of the control group(P<0.05).Conclusion Yiqi Yangxue Decoction in the treatment of VA-TIA vertigo with Qi and blood deficiency syndrome can help to improve symptoms and cerebral artery blood flow speed,reduce blood viscosity and improve hemorheology,with remarkable effect.