中西医结合治疗小儿支原体肺炎湿热蕴肺型40例临床观察

Clinical observation on 40 cases of mycoplasma pneumoniae pneumonia with accumulation of damp-heat in lung in children treated by integrating therapy of Chinese and Western medicine

目的观察中西医结合治疗小儿支原体肺炎(MPP)湿热蕴肺型的临床疗效。方法选取2016年6月至2017年9月在我院治疗的MPP湿热蕴肺型患儿80例,随机分为对照组和治疗组,各40例。对照组给予常规抗感染对症治疗,治疗组在对照组治疗方法的基础上予甘露消毒丹加减。治疗2周后观察2组治疗1周和2周的肿瘤坏死因子(TNF-α)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)变化水平及呼吸音异常、高热、胸闷和气促改善情况,高热、咳嗽、痰中带血持续时间情况。结果治疗前,2组TNF-α、CRP及IL-6水平及呼吸音异常、高热、胸闷及气促例数比较,差异均无统计学意义(P>0.05),具有可比性。与同组治疗前和治疗1周比较,治疗2周时2组TNF-α、CRP及IL-6水平显著下降,呼吸音异常、高热、胸闷及气促例数显著减少,差异均有统计学意义(P<0.05),且治疗组下降或减少更显著,与对照组比较,差异均有统计学意义(P<0.05)。治疗组高热、咳嗽、痰中带血持续时间均短于对照组,差异有统计学意义(P<0.05)。结论中西医结合治疗小儿MPP湿热蕴肺型,可显著改善患儿的临床症状,促进疾病恢复,值得临床推广应用。

Objective To observe the clinical efficacy of mycoplasma pneumoniae pneumonia(MPP)with accumulation of damp-heat in lung in children treated by integrating therapy of Chinese and Western medicine.Methods Eighty cases of MPP with accumulation of damp-heat in lung from June 2016 to September 2017 in our hospital were randomly divided into control group and treatment group,with 40 cases in each.The control group was given routine anti-infection and symptomatic treatment,while the treatment group was given modified Ganlu Xiaodu Dan(甘露消毒丹)on the basis of the control group.After treated for 2 weeks,the levels of TNF-α,CRP,IL-6 and the improvement of abnormal breath sounds,hyperthermia,chest tightness and shortness of breath,duration of hyperthermia,duration of cough,and time of blood-tinged sputum in the 2 groups at the 1 st and 2 nd week were observed.Results Before treatment,the levels of TNF-α,CRP,IL-6,abnormal breath sounds,hyperthermia,chest tightness and shortness of breath in both groups were compared,and the difference was not statistically significant(P>0.05),and they were comparable.The levels of TNF-α,CRP and IL-6,abnormal breath sounds,hyperthermia,chest tightness and shortness of breath decreased significantly in the 2 groups after 2 weeks of treatment,compared with those in the same group before and after 1 week of treatment,and the difference was statistically significant(P<0.05).Moreover,those in the treatment group decreased more significantly,there was statistical significance compared with those in the control group(P<0.05).Duration of hyperthermia,duration of cough,and time of blood-tinged sputum in the treatment group were all shorter than those in the control group,there was statistical significance(P<0.05).Conclusion MPP with accumulation of damp-heat in lung in children treated by integrating therapy of Chinese and Western can significantly improve the clinical symptoms of the children patients,promote the recovery of the disease and deserves clinical promotion and application.