摘要
黄芩为我国中药及其复方中常用的一种传统中药材,广泛分布在我国陕西、内蒙等地。近年来,已发现黄芩具有抗肿瘤、抗艾滋病和神经保护等生物活性,具有很大的应用前景。本文概括了黄芩中的主要化学成分、药理活性及质量控制状况。黄芩中含有黄酮、挥发油及萜类等化合物,黄酮类化合物是最重要的活性物质。基于中药质量标志物的核心概念,对黄芩的质量标志物进行了预测分析,为建立和完善黄芩中药材的质量标准提供参考和借鉴。
Scutellariae Radix is a commonly used traditional Chinese medicine in Chinese herbs and formula. It is mainly distributed in Shanxi and Inner Mongolia provinces of China. In recent years, it was found that Scutell Ariae Radix has bioactivities, such as antitumor, anti-AIDS and neuroprotective, and great application prospects. In this paper, chemical composition, pharmacological activities and current state of quality control of Scutellariae Radix are summarized. The chemical compositions of Scutellariae Radix include flavonoids, volatile oil and terpenoidsetc, in which flavonoids are the main activity-related drug compositions. Based on the core concepts of quality marker, quality marker components of Scutellariae Radix are predicted and analyzed, in order to provide references for establishing and improving the quality standards of Scutellariae Radix.
作者
黄光强
梁洁
林婧
陈晓思
信晨曦
杨川川
周昱杉
HUANG Guang-qiang;LIANG Jie;LIN Jing;CHEN Xiao-si;XIN Chen-xi;YANG Chuan-chuan;ZHOU Yu-shan(Facutly of Pharmary,Guangxi University of Chinese Medicine,Guangxi Zhuang Yao Medicine Center of Engineering and Technology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning 530200,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2020年第3期285-292,共8页
Chinese Journal of New Drugs
基金
国家自然科学基金资助项目(81560691)
广西创新驱动发展专项资金资助项目(桂科AA17202046)
广西中医药大学“岐黄工程”高层次人才团队培育资助项目(2018002)
广西中医药大学中药学博士点建设工程开放课题资助项目(201410-06)
广西一流学科建设重点课题资助项目(2018XK049)
广西高校中药提取纯化与质量分析重点实验室自主研究课题资助项目(2016-5)
壮瑶药协同创新中心资助项目(桂教科研[2013]20号)
广西壮瑶药重点实验室资助项目(桂科基字[2014]32号)
国家中医药管理局科研三级实验室中(壮)药化学与质量分析实验室资助项目(国中医药发2009[21]号)
广西高校中药提取纯化与质量分析重点实验室资助项目(桂教科研[2014]6号)
广西高等学校千名中青年骨干教师培育计划(桂教人[2019]5号)
广西高等学校高水平创新团队及卓越学者计划项目(桂教师范[2019]52号)
第八批广西壮族自治区特聘专家项目(壮瑶药质量标准研究,桂人才通字[2019]13号).
关键词
黄芩
质量控制
黄酮
质量标志物
Scutellariae Radix
quality control
flavonoids
quality marker
