芪苈强心胶囊联合替罗非班在心肌梗死治疗中的临床效果观察

Clinical observation of Qiliqiangxin capsule combined with Tirofiban in the treatment of myocardial infarction

目的:探究芪苈强心胶囊联合替罗非班治疗急性心肌梗死(AMI)的临床效果。方法:于2020年9月—2022年9月本院收治的AMI患者中选取98例作为研究对象,并按随机数表法分成对照组(49例)和观察组(49例)。对照组静脉注射替罗非班,观察组在静脉注射替罗非班的基础上口服芪苈强心胶囊,治疗时限均为6个月。比较两组的疗效、心功能指标[左心室收缩末期内径(LVESD)、舒张末期内径(LVEDD)、射血分数(LVEF)]、血清因子[胱抑素C(Cys C)、脑钠钛(BNP)、肌钙蛋白Ⅰ(c TnⅠ)]水平和不良反应发生率。结果:观察组治疗后总有效率(95.92%,47/49)高于对照组(83.67%,41/49)(P<0.05);两组治疗后的LVESD、LVEDD均低于同组治疗前,LVEF高于同组治疗前,且观察组治疗后变化幅度高于对照组(P<0.05);两组治疗后的Cys C、BNP、cTnⅠ水平均低于同组治疗前(P<0.05),且观察组治疗后各指标水平均低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:芪苈强心胶囊联合替罗非班治疗AMI疗效显著,能有效改善心功能,延缓心肌损伤程度,且应用较安全。

Objective:To explore the clinical curative effect of Qili Qiangxin capsule combined with tirofiban on patients with acute myocardial infarction(AMI).Methods:A total of 98 patients with AMI admitted to the hospital were enrolled as the research objects between September 2020 and September 2022.According to random number table method,they were divided into control group(49 cases)and observation group(49 cases).The control group was given intravenous injection of tirofiban,while observation group was additionally given oral Qili Qiangxin capsules.All were treated for 6 months.The curative effect,cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF)],serum factors[cystatin C(Cys C),brain natriuretic peptide(BNP),cardiac troponin I(cTnI)]and the incidence of adverse reactions during treatment were compared between the two groups.Results:After treatment,total response rate of observation group was higher than that of control group(95.92%,47/49 vs 83.67%,41/49,P<0.05).After treatment,LVESD and LVEDD were decreased,while LVEF was increased in both groups,and the changes amplitude was greater in observation group than control group(P<0.05).After treatment,levels of Cys C,BNP and cTnI in both groups were decreased(P<0.05),which were lower in observation group than control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The curative effect of Qili Qiangxin capsule combined with tirofiban is significant on AMI patients,which can effectively improve cardiac function and delay myocardial injury,with high application safety.