研究尼可地尔对急性心肌梗死患者冠状动脉介入术后心功能及临床预后的影响

Study the Effect of Nicorandil on the Cardiac Function and Clinical Prognosis of Patients with Acute Myocardial Infarction after Coronary Intervention

目的研究尼可地尔对急性心肌梗死患者冠状动脉介入术后心功能及临床预后的影响。方法本次研究的对象为2019年4月-2020年4月冠状动脉介入术的急性心肌梗死患者,分为两组,每组50例。对照组患者给予常规治疗;观察组患者在对照组基础上给予尼可地尔进行治疗,观察对比两组患者治疗后心功能及临床预后情况。结果观察组患者的心肌酶指标更低,两组对比差异具有统计学意义(P<0.05);观察组患者的NT-proBNP水平明显低于对照组患者,差异具有统计学意义(P<0.05);观察组患者的在院心脏事件明显更低,观察组患者的再次住院情况明更低,差异具有统计学意义(P<0.05);观察组患者的手术后不同时间点的左心室射血分数(LVEF)指标明显高于对照组,差异具有统计学意义(P<0.05);观察组患者的手术后不同时间点的左心室舒张期末容积指数(LVEDVI)指标明显低于对照组,差异具有统计学意义(P<0.05)。结论在常规治疗基础给予冠状动脉介入术后的急性心肌梗死患者进行尼可地尔治疗效果十分显著,可明显患者心功能和临床预后,非常具有临床价值,值得推荐。

Objective To study the effect of nicorandil on the cardiac function and clinical prognosis of patients with acute myocardial infarction after coronary intervention.Methods The subjects of this study are patients with acute myocardial infarction who underwent coronary intervention from April 2019 to April 2020,divided into two groups with 50 cases in each group.Patients in the control group were given conventional treatment.Patients in the observation group were treated with nicorandil on the basis of the control group.Observe and compare the cardiac function and clinical prognosis of the two groups of patients after treatment.Results The myocardial enzyme index of the observation group was lower,and the difference between the two groups was statistically significant(P<0.05).The NT-proBNP level of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).The cardiac events in the observation group were significantly lower,and the rehospitalization of patients in the observation group was significantly lower,and the difference was statistically significant(P<0.05).The left ventricular ejection fraction(LVEF)indicators of the observation group at different time points after surgery were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).The left ventricular end diastolic volume index(LVEDVI)indicators of the observation group at different time points after surgery were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Nicorandil is very effective for patients with acute myocardial infarction after coronary intervention on the basis of conventional treatment.It can clearly show the cardiac function and clinical prognosis of patients.It has clinical value and is worth recommending.