杜仲不同部位化学成分及药理作用研究进展

Research advances in chemical constituents and pharmacological activities of different parts of Eucommia ulmoides

杜仲在我国有两千多年的用药历史,现代研究显示杜仲不同部位(皮、叶、花、种子等)包含多种化学成分,包括木脂素类、环烯醚萜类、酚酸类、黄酮类、萜类和甾体类、多糖类等成分,目前已有的报道,杜仲中共分离得到205种化合物,其药理作用主要有降压、降血糖、调节血脂、预防骨质疏松、抗炎、肝保护、抗肿瘤等,不同部位功效及机制不完全相同。该文对杜仲不同部位的化学成分和药理作用及其机制进行了系统的总结,并对药材质量控制和炮制研究方面进行了分析,以期为杜仲深入研究和合理开发利用提供理论依据。

To date,205 compounds have been identified from different medicinal parts of Eucommia ulmoides,including lignans,iridoid terpenoids,phenols,flavonoids,terpenoids and steroids,polysaccharides and others.Their pharmacological effects include blood pressure-lowering,blood sugar-lowering,blood lipids-regulating,prevention of osteoporosis,anti-inflammation,liver protection,anti-cancer and so on.Their efficacy and mechanism from different parts are slightly different.In this paper,the chemical composition,pharmacological action and mechanism of different parts of E.ulmoides were systematically summarized,as well as its quality control and processing research,to provide theoretical basis for further rational development and utilization of E.ulmoides.