新型HIV-1蛋白酶抑制剂的研究进展(2015~2019年)

Research progress in the development of HIV-1 protease inhibitors(2015-2019)

获得性免疫缺陷综合征是由人类免疫缺陷病毒(HIV)感染引起的一种全球性流行疾病。针对HIV-1复制周期中的不同过程已有多种抗HIV-1药物应用于临床,其中HIV-1蛋白酶抑制剂通过干扰病毒成熟所需蛋白的产生来阻断病毒的复制,在抗病毒治疗中起着重要的作用,新型蛋白酶抑制剂的研发一直是抗HIV-1药物研究的热点和重点。本文对近5年来报道的新型HIV-1蛋白酶抑制剂的研究现状进行简要综述。

Acquired immune deficiency syndrome(AIDS)is a global epidemic caused by human immunodeficiency virus(HIV).In the HIV-1 life cycle,HIV-1 protease is one of the most important therapeutic targets for the treatment of HIV infection.HIV-1 protease inhibitors,which block the production of essential viral proteins required for mature virions,play a crucial role in reducing the spread of HIV.Over the years,numerous efforts have been undertaken to develop novel protease inhibitors.In this review,a brief summary about the current progress of novel HIV-1 protease inhibition in recent five years was summarized.