2018年广西壮族自治区1-59岁人群乙型肝炎血清流行率调查

Sero-prevalence of hepatitis B among people aged 1-59 years in Guangxi Zhuang Autonomous Region,2018

目的了解广西壮族自治区2018年1-59岁人群乙型肝炎病毒(HBV)血清流行率。方法采用分层随机抽样在广西14个市选择40个县1-59岁常住人群进行问卷调查和采集血标本,检测HBV表面抗原(HBsAg)、HBV表面抗体(HBsAb)、HBV核心抗体(HBcAb)、HBV e抗原(HBeAg)和HBV e抗体(HBeAb),分析血清流行率。结果共纳入研究对象10256名,HBsAg、HBsAb、HBcAb阳性率分别为4.3%、59.3%、24.1%(标化值:7.2%、58.3%、41.2%);其中HBsAg、HBcAb阳性率随年龄增加而上升,<15岁儿童HBsAb阳性率随年龄增加而下降。年龄、地区、性别、民族、职业、文化程度、婚姻状况、乙肝疫苗(HepB)免疫史是HBsAg阳性率的显著影响因素。在438例HBsAg阳性人群中,HBeAg、HBeAb阳性率分别为22.8%、73.2%。结论实施HepB免疫策略对广西儿童乙肝的防控成效显著。应加强适龄儿童HepB接种,探索成人HepB免疫策略。

Objective To determine the sero-prevalence of hepatitis B virus(HBV)markers among people aged 1-59 years in Guangxi Zhuang Autonomous Region in 2018.Methods We used a stratified random sampling method to select a local population,aged 1-59 years residing in one of 40 counties in 14 prefectures of Guangxi,to conduct a questionnaire-based survey and obtain blood samples to test for HBV surface antigen(HBsAg),HBV surface antibody(HBsAb),HBV core antibody(HBcAb),HBV e antigen(HBeAg),and HBV e antibody(HBeAb).We determined sero-prevalence using these data.Results Among the 10256 subjects recruited,positivity rates of HBsAg,HBsAb,HBcAb were 4.3%,59.3%,and 24.1%(ad justed:7.2%,58.3%,and 41.2%),respectively.Positivity rates of HBsAg and HBcAb increased with increasing age,while positivity rate of HBsAb among<15 year old children decreased with increasing age.Factors significantly influencing HBsAg positivity rate included age,region,gender,ethnicity,occupation,education,marriage status,and hepatitis B vaccine(HepB)immunization history.Of 438 subjects who were HBsAg positive,positivity rates of HBeAg and HBeAb were 22.8%and 73.2%,respectively.Conclusion The hepatitis B immunization strategy had a significant effect on hepatitis B prevention and control among children in Guangxi.We should strengthen HepB vaccination for age-eligible children and explore HepB vaccination strategies for adults.