中国2017年疑似预防接种异常反应监测

Surveillance of adverse events following immunization in China,2017

目的分析中国2017年疑似预防接种异常反应(Adverse events following immunization,AEFI)流行病学特征。方法通过中国免疫规划信息管理系统AEFI监测系统和常规接种率监测系统分别收集2017年发生的AEFI个案数据、疫苗接种数据,对AEFI特征进行描述流行病学分析。结果中国2017年共报告210181例AEFI,总报告发生率为38.94/10万剂;其中一般反应193113例(35.77/10万剂)、异常反应14273例(2.64/10万剂)。在异常反应中,严重异常反应711例(0.13/10万剂);过敏性皮疹11985例(2.22/10万剂)、卡介苗淋巴结炎513例(2.95/10万剂)、血管性水肿347例(0.06/10万剂)、热性惊厥275例(0.05/10万剂)、卡介苗局部脓肿200例(1.15/10万剂)。结论中国2017年报告AEFI以一般反应为主,严重异常反应报告发生率极低。

Objective To describe characteristics and incidence of adverse events following immunization(AEFIs)in China in 2017.Methods We used the National Immunization Program Information Management System to obtain data on reported AEFI cases and vaccine doses administered in 2017 for a descriptive epidemiological analysis.Results In total,210181 AEFIs were reported,for an estimated incidence of 38.94 cases per 100000 doses administered.Of these reports,193113(35.77 per 100000)were for common vaccine reactions and 14273(2.64 per 100000)were for rare vaccine reactions.Among the rare vaccine reactions,711(0.13 per 100000)were serious reactions,11985(2.22 per 100000)were anaphylactic rash,513(2.95 per 100000)were lymphadenitis af ter Bacilli Calmette-Guérin(BCG)vaccination,347(0.06 per 100000)were angioedema,275(0.05 per 100000)were febrile convulsions,and 200(1.15 per 100000)were local abscesses af ter BCG vaccination.Conclusion Most reported AEFIs were common vaccine reactions in China in 2017;there was an extremely low incidence of serious vaccine reactions.