复方丹参颗粒、复方丹参胶囊、复方丹参片与复方丹参滴丸对冠心病心绞痛患者疗效、炎性因子及氧化应激指标的影响

Effect of Compound Danshen granules, capsules, tablets, and drop pills on curative effect, inflammatory factors, and oxidative stress indexes of angina pectoris patients with coronary heart disease

目的探讨不同复方丹参制剂对冠心病心绞痛患者疗效、炎性因子及氧化应激指标的影响。方法采用随机数字表法将2013年5月—2017年11月陕西省人民医院收治的364例冠心病心绞痛患者分为颗粒剂组、胶囊剂组、片剂组及滴丸剂组,每组91例。4组均给予常规治疗,包括给予硝酸甘油、阿司匹林等。在常规治疗基础上,颗粒剂组、胶囊剂组、片剂组及滴丸剂组分别口服复方丹参颗粒,1袋/次,3次/d;复方丹参胶囊,3粒/次,3次/d;复方丹参片,3片/次,3次/d;复方丹参滴丸,10丸/次,3次/d。4组均治疗3个月。治疗后,比较4组患者的临床疗效、症状缓解情况(每天平均心绞痛发作次数、平均心绞痛持续时间及平均硝酸甘油使用量)和血清炎性因子[超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、脂蛋白相关磷脂酶A2(Lp-PLA2)及可溶性细胞间黏附分子-1(sICAM-1)]水平,氧化应激指标[总抗氧化能力(TAoc)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-PX)及超氧化物歧化酶(SOD)]水平。结果治疗3个月后,滴丸剂组总有效率明显高于颗粒剂组、胶囊剂组及片剂组(P<0.05)。治疗3个月后,4组患者心绞痛发作次数、平均心绞痛持续时间及平均硝酸甘油使用量均明显降低(P<0.05),且滴丸剂组均明显低于其余3组(P<0.05)。治疗3个月后,4组患者hs-CRP、IL-6、Lp-PLA2和sICAM-1水平均明显降低(P<0.05),且滴丸剂组均明显低于其余3组(P<0.05)。治疗3个月后,4组患者T-Aoc、MDA、GSH-PX及SOD水平均明显改善(P<0.05),且滴丸剂组改善程度均明显优于其余3组(P<0.05)。结论与复方丹参颗粒、复方丹参胶囊、复方丹参片相比较,复方丹参滴丸治疗冠心病心绞痛具有更好的疗效,且能够更有效的改善患者症状、炎症情况及机体氧化应激损伤。

Objective To explore the effect of different Compound Danshen Preparation on curative effect,inflammatory factors,and oxidative stress indexes of angina pectoris patients with coronary heart disease.Methods 364 cases of angina pectoris patients with coronary heart disease in Shaanxi Provincial People’s Hospital from May 2013 to November 2017 were divided into granule group,capsule group,tablet group and drop pills group,each group had 91 cases.All patients were treated by regular method,including nitroglycerin and aspirin.On the basis of regular method,granule group,capsule group,tablet group and drop pills group were treated by Compound Danshen Granules,1 bag/time,three times daily,Compound Danshen Capsules,3 grains/time,three times daily,Compound Danshen Tablets,3 tablets/time,three times daily,and Compound Danshen Drop Pills,10 pills/time,three times daily,respectively.Patients in four groups were treated for 3 months.After treatment,the clinical efficacy,clinical symptomatic remissions(mean times of angina pectoris attack,duration of angina pectoris,and the dosage of nitroglycerin),and the levels of serum inflammatory factors(hs CRP,IL-6,Lp-PLA2 and sICAM-1),and the levels of oxidative stress indexes(T-AOC,MDA,GSH-Px,and SOD)in four groups were compared.Results After treatment of 3 months,the total effective rate in the drop pills group was significantly higher than granule group,capsule group and tablet group(P<0.05).After treatment of 3 months,the mean times of angina pectoris attack,duration of angina pectoris,and the dosage of nitroglycerin in the four groups significantly decreased(P<0.05),and the drop pills group were significantly lower than other groups(P<0.05).After treatment of 3 months,the levels of hs-CRP,IL-6,Lp-PLA2 and sICAM-1 in four groups were significantly decreased(P<0.05),and the indexes in the drop pills group were significantly lower than other three groups(P<0.05).After treatment of 3 months,the levels of T-Aoc,MDA,GSHPX and SOD in four groups were significantly promoted,and the these indexes in the drop pills group were significantly better than the other three groups(P<0.05).Conclusion Compared with Compound Danshen Granules,Compound Danshen Capsules,and Compound Danshen Tablets,Compound Danshen Drop Pills has better effects in treatment of angina pectoris patients with coronary heart disease,could release the patient’s symptoms,and improve the inflammation and oxidative stress of patient.