女珍颗粒联合佐匹克隆治疗更年期失眠症的临床研究

Clinical study of Nüzhen Granules combined with zopiclone in treatment of menopause insomnia

目的探讨女珍颗粒联合佐匹克隆片治疗更年期失眠症的临床疗效。方法选取2016年3月—2018年10月在内蒙古自治区精神卫生中心进行治疗的82例更年期失眠患者为研究对象,根据用药的差别分为观察组(41例)和对照组(41例)。对照组给予佐匹克隆片,7.5 mg/次,1次/d,睡前服用;观察组在对照组基础上口服女珍颗粒,6 g/次,3次/d。两组均治疗4周后进行效果对比。结果经治疗,对照组有效率为82.92%,显著低于治疗组95.12%(P<0.05)。经治疗,两组患者匹兹堡睡眠质量指数量表(PSQI)评分降低;多导睡眠监测(PSG)中入睡时间、觉醒时间降低,总睡眠时间增加,睡眠效率提高;睡眠结构中I期时间缩短,II、III期及快速动眼期时间延长(P<0.05),且观察组睡眠情况显著优于对照组(P<0.05)。经治疗,两组患者血清中神经递质去甲肾上腺素(NE)、5-羟色胺(5-HT)、多巴胺(DA)水平显著升高(P<0.05),且观察组神经递质水平显著高于对照组(P<0.05)。经治疗,两组焦虑自评量表评分(SAS)、抑郁自评量表评分(SDS)、SCL-90、Hamilton抑郁量表(HAMD)评分均显著降低(P<0.05),且观察组上述评分显著低于对照组(P<0.05)。结论女珍颗粒联合佐匹克隆片治疗更年期失眠症效果良好,可有效减轻失眠症状,改善患者负面情绪,提高患者生活质量,有着良好临床应用价值。

Objective To investigate the clinical efficiency of Nüzhen Granules combined with Zopiclone Tablets in treatment of menopause insomnia.Methods Patients(82 cases)with menopause insomnia treated in Mental Health Center of Inner Mongolia Autonomous Region from March 2016 to October 2018 were divided into observation group(41 cases)and control group(41 cases)according to the medication.The control group was given Zopiclone Tablets before bedtime,7.5 mg/time,once daily.Patients in the observation group was given Nüzhen Granules on the basis of the control group,6 g/time,three times daily.The two groups were compared after 4 weeks of treatment.Results After treatment,the effective rate of the control group was 82.92%,which was significantly lower than 95.12%of the treatment group(P<0.05).After treatment,the PSQI score in two groups were decreased.In PSG,sleep time and wake time were decreased,and the total sleep time was increased,and sleep efficiency was improved.In the sleep structure,stage I duration was shortened,stage II,III and rem duration was prolonged(P<0.05),and the sleep status in the observation group was significantly better than that in the control group(P<0.05).After treatment,serum NE,5-HT,DA levels in two groups were significantly increased(P<0.05),and the neurotransmitter levels in the observation group was significantly higher than those in the control group(P<0.05).After treatment,the scores of SAS,SDS,SCL-90,and HAMD in two groups were significantly decreased(P<0.05),and the scores in the observation group was significantly lower than those in the control group(P<0.05).Conclusion Nüzhen Granules combined with Zopiclone Tablets is effective in treating menopausal insomnia.It can effectively alleviate the symptoms of insomnia,improve the negative emotions of patients,improve the quality of life,and it has good clinical application value.