慢性阻塞性肺疾病与水通道蛋白-1和5的关系及中医药干预的影响

Research Progress of Influence of Traditional Chinese Medicine on Aquaporin-1 and 5 in Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病是全球难治性疾病,其病程长,发病机制复杂,涉及多种发病因素。近年来,大量有关中医药治疗慢性阻塞性肺疾病的研究见诸于报道,提出中医药可通过干预水通道蛋白-1和5对慢性阻塞性肺疾病肺部炎症及气道黏液高分泌等病理变化发挥调节作用。此外,也有研究表明水通道蛋白-1和5与慢性阻塞性肺疾病发病过程密切相关,且不同程度地参与了慢性阻塞性肺疾病的气道炎症、气道黏液高分泌等病理过程。就水通道蛋白-1和5在肺部表达情况及其与慢性阻塞性肺疾病的关系,以及中医药干预水通道蛋白-1和5对慢性阻塞性肺疾病的影响进行了论述。

The Chronic Obstructive Pulmonary Disease(COPD)is a global disease,which has a long course,complex pathogenesis and involves many factors.In recent years,more and more studies on the role of traditional Chinese medicine in the treatment of chronic obstructive pulmonary disease have been reported.It has been found that traditional Chinese medicine can play an important role in the regulation of COPD pulmonary inflammation and airway mucus hypersecretion by intervening aquaporin-1 and 5 and it also has been found that aquaporins-1 and 5 are closely related to the COPD,which are involved in the pathogenesis of COPD,such as airway inflammation,airway mucus secretion imbalance and so on.Herein is a review of the expression of aquaporin-1 and 5 in the lung and the relationship between aquaporin-1 and 5 and COPD,as well as the influence of traditional Chinese medicine on aquaporin-1 and 5.