摘要
目的了解铁路司机幽门螺杆菌(HP)的感染状况,分析HP感染与血清胆红素的相关性。方法采用判断抽样方法,选择2731名郑州机务段铁路司机为研究对象,采用碳13尿素呼气试验评估其HP感染状况,比较HP阳性组和HP阴性组人群的代谢指标水平,分析HP感染与血清胆红素的关系。结果研究对象HP感染率为42.3%(1156/2731)。年龄越大、工龄越长、体质量指数(BMI)越高者,HP感染率均越高(P值均<0.01);已婚者HP感染率高于未婚者(P<0.01),吸烟者HP感染率高于不吸烟者(P<0.01)。与HP阴性组比较,HP阳性组人群的空腹血糖和血清总胆固醇、低密度脂蛋白胆固醇(LDL-C)、三酰甘油、同型半胱氨酸(Hcy)水平均升高(P值均<0.05),血清高密度脂蛋白胆固醇(HDL-C)、总胆红素、直接胆红素(DBIL)和间接胆红素水平均下降(P值均<0.05)。logistic回归分析结果显示,调整年龄、工龄、婚姻状况、吸烟史、空腹血糖、总胆固醇、三酰甘油、LDL-C、HDL-C和Hcy等的混杂影响后,HP感染与血清低水平总胆红素、低水平DBIL均存在关联(P值均<0.01)。结论铁路司机的年龄、工龄、BMI、吸烟和婚姻状态是HP感染的影响因素;HP感染与低水平总胆红素和DBIL水平相关。
Objective To investigate the infection status of Helicobacter pylori(HP),and analyze the correlation between HP infection and serum bilirubin in railway drivers.Methods A total of 2731 railway drivers in Zhengzhou locomotive depot were selected as study subjects using judgment sampling method.Carbon-13 urea breath test was used to evaluate the HP infection status.The metabolic indexes of HP positive group and HP negative group were compared,and the relationship between HP infection and serum bilirubin was analyzed.Results The HP infection rate was 42.3%(1156/2731).The older the age,the longer the work years,and the higher the body mass index(BMI),the higher the HP infection rate(all P<0.01).The infection rate of HP in married people was higher than that in unmarried people(P<0.01).The HP infection rate of smokers was higher than that of non-smokers(P<0.01).Compared with the HP-negative group,fasting blood glucose and serum levels of total cholesterol,low density lipoprotein cholesterol(LDL-C),triglyceride and homocysteine(Hcy)were increased in the HP-positive group(all P<0.05).The serum levels of high density lipoprotein cholesterol(HDL-C),total bilirubin,direct bilirubin(DBIL)and indirect bilirubin were lower than those in HP-negative group(all P<0.05).Logistic regression analysis showed that HP infection was associated with low serum total bilirubin and low DBIL(all P<0.01)after adjusting for the confounding effects of age,work years,marital status,smoking history,fasting blood glucose,total cholesterol,triacylglycerol,LDL-C,HDL-C,and Hcy.Conclusion The age,work length,BMI,smoking and marital status are the influencing factors of HP infection in railway drivers.HP infection is associated with low levels of total bilirubin and DBIL.
作者
焦琳琳
张磊
李雨铮
靳超美
周蓉
张思雨
田梅
周舫
JIAO Lin-lin;ZHANG Lei;LI Yu-zheng;JIN Chao-mei;ZHOU Rong;ZHANG Si-yu;TIAN Mei;ZHOU Fang(School of Public Health,Zhengzhou University,Zhengzhou,Henan 450001,China;不详)
出处
《中国职业医学》
CAS
北大核心
2022年第5期577-581,585,共6页
China Occupational Medicine
基金
河南省自然科学基金(222300420537)
关键词
幽门螺杆菌
感染
血清
胆红素
相关性
铁路
司机
Helicobacter pylori
Infection
Serum
Bilirubin
Correlation
Railway
Driver