中期因子Midkine水平与儿童过敏性紫癜关系的Meta分析

Meta analysis of the relationship between Midkine level and children with Henoch Schonlein purpura

目的 评价中期因子(Midkine)水平与儿童过敏性紫癜(Henoch Schonlein purpura,HSP)的关系。方法 检索CNKI、CBM、CAJD、维普VIP、WangFang Data、PubMed、EMBase、Cochrane等数据库(检索时限截止至2021年10月),选择符合标准的临床试验,用Newcastle-Ottawa scale法对纳入研究的文献进行评估,用RevMan5.4软件进行Meta分析。结果 共纳入6篇文献,分3个亚组进行Meta分析,结果显示儿童血清中的MK水平,过敏性紫癜组(HSP)明显高于健康对照组(HC)、过敏性紫癜合并肾损害组(HSPN)明显高于健康对照组(HC)、HSPN组明显高于HSP组,且差异均有统计学意义(P <0.0001)。结论 HSP患儿及HSPN患儿的MK水平显著高于健康儿童,且HSPN患儿的MK水平显著高于HSP患儿,提示可以通过血清MK水平的变化,诊断儿童过敏性紫癜并预测患儿是否出现肾损害。但由于本研究纳入文献量有限,质量一般,因此仍有待开展多样本、多区域联合的临床试验进一步验证。

Objective To evaluate the relationship between Midkine level and Henoch Schonlein purpura in children.Methods CNKI,CBM,CAJD,VIP,Wangfang data,PubMed,EMBASE,Cochrane and other databases were searched(the limit of search time was up to the October of 2021).Theclinical trials that meet the criteriawere selected.The literatures included in the study were evaluated by the Newcastle-Ottawa scale,and meta-analysis was conducted with Revman5.4 software.Results A total of 6 studies and 3 groups were included.The results of meta-analysis showed that the level of MK in children's serum in HSP group was significantly higher than that in HC group,HSPN group was significantly higher than that in HC group,HSPN group was significantly higher than that in HSP group,and the difference was statistically significant(P<0.0001).Conclusion The MK level of HSP children and HSPN children is significantly higher than that of healthy children,and the MK level of HSPN children is significantly higher than that of HSP children,suggesting that the change of serum MK level can be used to diagnose Henoch Schonlein purpura in children and predict whether children have renal damage.However,due to the limited number and general quality of the literature included in this study,it still needs to be further verified by large sample and multi-center clinical trials.