原发性醛固酮增多症及其亚型与代谢综合征相关性Meta分析

Meta-analysisof the relationship between primary aldosteronism and its subtypes and metabolic syndrome

目的 本研究旨在分析原发性醛固酮增多症(primary aldosteronism,PA)与代谢综合征(metabolic syndrome,MS)的相关性。方法 在PubMed,Embase,万方网、中国知网(CNKI)、维普网(VIP)数据库中,查找从建库至2021年12月有关原发性醛固酮增多症合并代谢综合征患病情况的相关文献,使用stata 15,Revman 5.4.1统计学软件进行Meta分析。结果共纳入13项研究进行,其中共计1609例PA患者,1999例原发性高血压患者(Essential hypertension,EH),结果显示原发性醛固酮组和原发性高血压组代谢综合征患病差异有统计学意义[OR=1.50,95%CI(1.10,2.03)]。不同亚型的原发性醛固酮增多症与代谢综合征相关性的Meta分析提示差异统计学意义[OR=1.99,(95%CI:1.40,2.84)]。对纳入的研究进行亚组分析,结果提示欧洲人群相对于亚洲人群更容易患代谢综合征,差异有统计学意义[OR=1.585,95%CI(0.904,2.781)]。结论 原发性醛固酮增多症与代谢综合征存在相关性,且与不同亚型的相关程度不同,但今后仍需进行大样本量的流行病学调查研究验证。

Objective The purpose of this study was to systematically evaluate the correlation between primary aldosteronism and metabolic syndrome.Methods The relevant literatures about the prevalence of primary aldosteronism with metabolic syndrome from the establishment of the database to December 2021 were found in the databases of PubMed,Embase,WanFang,CNKI and VIP.Meta analysis was carried out by using stata15,Revman5.4.1 statistical software.Results A total of 13 studies were included,including 1609 patients with PA and 1999 patients with essential hypertension.The results showed that there was a significant difference in the prevalence of metabolic syndrome between primary aldosterone group and essential hypertension group[OR=1.50,95%CI(1.10,2.03)].Meta analysis of the relationship between different subtypes of primary aldosteronism and metabolic syndrome showed that the difference was statistically significant[OR=1.99,(95%CI:1.40,2.84)].Subgroup analysis of the included study,the results suggested that the European population was more likely to suffer from metabolic syndrome than the Asian population[OR=1.585,95%CI(0.904,2.781)].Conclusion There is a correlation between primary aldosteronism and metabolic syndrome,and the degree of correlation with different subtypes is different,but it still needs to be verified by epidemiological investigation with large sample size in the future.