苦杏仁苷自微乳的制备及理化性质的研究

Study on Preparation and Physicochemical Properties of Amygdalin Self-microemulsion

目的制备苦杏仁苷自微乳,并进行初步质量评价研究。方法通过平衡溶解度的测定和伪三元相图的绘制筛选苦杏仁苷的最佳处方,并对苦杏仁苷自微乳的粒径、多分散系数、稳定性进行评价。结果苦杏仁苷自微乳的最优处方为Peceol/MCT(1︰1)-乳化剂OP-1,2-丙二醇=45%︰40%︰15%,载药量为6 mg·mL^(-1)。所得苦杏仁苷自微乳平均粒径为(113.3±0.8)nm,多分散系数为(0.171±0.007),离心稳定性良好。结论优选处方稳定可行,制备的苦杏仁苷自微乳粒径均匀,稳定性良好。

OBJECTIVE To prepare amygdalin self-microemulsion and to carry out preliminary quality evaluation.METHODS The best prescription of amygdalin was screened by the determination of equilibrium solubility and drawing of pseudo-ternary phase diagram.The particle size,polydispersity coefficient and stability of amygdalin self-microemulsion were evaluated.RESULTS The optimum formulation of amygdalin self-microemulsion was Peceol/MCT(1︰1)-emulsifier OP-1,2-propanediol=45%︰40%︰15%with drug loading of 6 mg·mL^(-1).The average particle size of amygdalin self-microemulsion was(113.3+0.8)nm,and the polydispersity coefficient was(0.171+0.007).The centrifugal stability of amygdalin self-microemulsion was good.CONCLUSION The optimized formulation is stable and feasible,and the prepared amygdalin self-microemulsion has uniform particle size and good stability.