针灸促进创面修复的机制研究进展

Progress of researches on acupuncture-moxibustion promoting wound repair

创面是一种以皮肤缺损或功能受限为特征的常见外科疾病,针灸在创面修复过程中起到重要的作用。本文通过梳理针灸促进创面修复的相关机制研究文献,发现针灸可以改善创面血流灌注量、促进血管生成、增加成纤维细胞数量及调节胶原合成;同时针灸可通过抑制肿瘤坏死因子-α、白细胞介素等炎性因子的释放,上调转化生长因子-β、血管内皮生长因子的表达水平,影响磷脂酰肌醇3-激酶/蛋白激酶B、丝裂原活化蛋白激酶及晚期糖基化终末产物/糖基化终末产物受体等诸多信号通路促进创面修复。未来应深入研究多机制协同调控中心靶点,重点关注针灸在组织修复中的治疗手段、量效关系。

Wound is a common surgical disease characterized by skin defect or functional limitation.Studies have found that acupuncture-moxibustion plays an important role in wound healing.In this paper,we reviewed the mechanisms of acupuncturemoxibustion in promoting wound repair.Outcomes display that acupuncture-moxibustion has an action in promoting wound restoration by improving wound flow perfusion,promoting angiogenesis,increasing the number of fibroblasts and regulating collagen synthesis.In addition,acupuncture can effectively promote wound healing by controlling the release of inflammatory cytokines,upregulating the expression of growth factors such as vascular endothelial growth factor and transforming growth factor-β1,and affecting phosphatidylinositol-3-kinase/protein kinase B,mitogen-activated protein kinase and advanced glycation end products/receptor for AGEs signaling pathways.Based on the above studies,it is highly recommended that future studies should pay more attention to the multi-mechanism coordinated regulation target center,and the therapeutic means and dose-effect relationship of acupuncture-moxibustion in tissue repair.