免疫微环境介导的肿瘤耐受机制及其靶向治疗

Tumor Immune Microenvironment:Challenge and Also the New Target of the Anti-Tumor Therapy

肿瘤微环境是肿瘤细胞赖以生存的特殊环境,包括肿瘤间质、邻近细胞、血管周边多种免疫细胞和免疫相关介质等组分。肿瘤微环境中各个组分的变化对肿瘤生长、侵袭、转移以及肿瘤的免疫耐受都产生了重要的影响。肿瘤免疫治疗是继放疗、化疗和手术治疗之后的第四种有效的治疗方法。但是大量的临床研究证实,肿瘤免疫疗法的临床治疗效果会受到肿瘤免疫微环境的影响。深入研究肿瘤微环境可以为肿瘤免疫疗法提供新的靶点,避免现有免疫疗法的免疫耐受现象,并为个性化精准医疗提供可能。该综述总结了肿瘤微环境对肿瘤免疫治疗的影响,旨在提出以免疫微环境为靶点的肿瘤免疫治疗新策略。

The tumor microenvironment is a special place for the living of tumor cells,consists of tumor mesenchyme,adjacent cells,blood vessels-various immune cells cytokines and chemokines.Changes in the components of tumor microenvironment may have an important impact on tumor growth,invasion,metastasis,and anti-tumor immune tolerance.Tumor immunotherapy is recently identified as an effective anti-tumor treatment after radiotherapy,chemotherapy and surgery.Many clinical studies have confirmed that the clinical therapeutic effect of tumor immunotherapy would be affected by the tumor immune microenvironment.Therefore,targeting tumor microenvironment could provide a new strategy for tumor immunotherapy to avoid the immune tolerance of existing immunotherapy,and provide therapeutic opportunities for personalized precision medicine.This review summarizes the impact of tumor microenvironment dynamics on tumor immunotherapy and aims to propose new anti-tumor therapeutic strategies by targeting immune microenvironment.