红细胞分布宽度与儿童过敏性紫癜性肾炎的相关性分析

Correlation Analysis Between Red Blood Cell Distribution Width and Allergic Purpura Nephritis in Children

目的:探讨红细胞分布宽度(RDW)与儿童过敏性紫癜性肾炎(HSPN)的相关性。方法:选取郑州大学附属儿童医院自2018年4月至2021年4月收治的50例HSPN患儿为HSPN组,同期收治的过敏性紫癜(HSP)患儿及健康体检儿童各50例,分别为HSP组、健康组。比较三组儿童的血常规指标、HSPN不同病理分级患儿的RDW水平,分析RDW与HSPN相关性。结果:HSP组、HSPN组的白细胞、中性粒细胞计数均高于健康组,血红蛋白均低于健康组,HSPN组血红蛋白和RDW高于HSP组,差异均具有统计学意义(P<0.05)。HSPNⅡ、Ⅲ级患儿RDW水平高于Ⅰ级、HSPNⅢ级高于Ⅱ级,差异均具有统计学意义(P<0.05)。Spearman相关分析结果显示,HSPN病情的严重程度和RDW呈正相关(r=0.794,P<0.001)。受试者工作特征(ROC)曲线结果显示,当RDW截断值取13.5%时,诊断HSPN曲线下面积最大,为0.964,95%CI(0.932,0.996),P<0.001,灵敏度为98.00%,特异度为88.00%。结论:RDW和儿童HSPN病情的严重程度呈正相关,对诊断儿童HSPN具有一定的价值,可为临床治疗提供参考。

Objective To investigate the relationship between red blood cell distribution width(RDW)and Henoch-Schonlein purpura nephritis(HSPN)in children.Methods A total of 50 children with HSPN admitted to Children’s Hospital Affiliated to Zhengzhou University from April 2018 to April 2021 were selected as the HSPN group,and 50 children with Henoch-Schonlein purpura(HSP)and 50 healthy children who underwent physical examination during the same period were selected as HSP group and healthy group respectively.The three groups were compared in terms of blood routine indexes and RDW levels in children with different pathological grades of HSPN,and the correlation between RDW and HSPN were analyzed.Results The white blood cell and neutrophil counts in the HSP group and HSPN group were higher than those in the healthy group,and the hemoglobin and RDW in the HSPN group were higher than those in the HSP group,and the differences were statistically significant(P<0.05).The RDW level of children with grade HSPNⅡ,Ⅲwere higher than those of the gradeⅠ,and the RDW level of children with grade HSPNⅢwas higher than that of the gradeⅡ,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that the condition severity of HSPN was positively correlated with RDW(r=0.794,P<0.001).The results of receiver operating characteristic(ROC)curve showed that when the cut-off value of RDW was 13.5%,the area under the curve was 0.964,95%CI(0.932,0.996),P<0.001,the sensitivity was 98.00%,and the specificity was 88.00%for the diagnosis of HSPN.Conclusion The RDW is positively correlated with the severity of HSPN in children,which has a certain value in the diagnosis of HSPN in children and can provide reference for clinical treatment.