小剂量短疗程氢化可的松治疗CAP相关脓毒症患儿效果分析

Effect analysis of small dose and short course hydrocortisone on CAP-related sepsis in children

目的探讨小剂量短疗程氢化可的松治疗社区获得性肺炎(CAP)相关脓毒症患儿的效果。方法按照随机数字表法把本院2018年3月至2019年11月收治的73例患有社区获得性肺炎相关脓毒症的患儿分为对照组和观察组。对照组35例予以抗病毒和抗生素治疗,观察组38例在对照组的基础上予以小剂量短疗程氢化可的松。比较两组治疗效果,胸腔积液、肺水肿情况,炎性细胞因子水平,不良反应。结果治疗后,观察组总有效率明显高于对照组;观察组患儿胸腔积液、肺水肿比例较对照组低;观察组C反应蛋白,降钙素原均明显低于对照组;不良反应发生率两组比较差异无统计学意义。结论小剂量短疗程氢化可的松治疗CAP相关脓毒症显著减少患儿胸腔积液、肺水肿情况,降低炎性细胞因子水平,临床效果更佳。

Objective To investigate the efficacy of short corse hydrocortisone in the treatment of sepsis associated with community acquired pneumonia(CAP).Methods According to the random number table method,73 children with community-acquired pneumonia-related sepsis admitted to our hospital from March 2018 to November 2019 were divided into control group and ovservation group.35 cases in the control group were treated with antiviral and antibiotics,and 38 cases in the observation grouup were with hydrocortisone in addition to the control group.The treatment effect,pleural effusion,pulmonary edema,inflammatory cytokine level and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of observation group was significantly higher than the control group.The proportion of pleural effusion and pulmonary edema in the observation group was lower than that in the control group.The CRP and procalcitonin in observation group were significantly lower than those in the control group.There was no significant difference in the incidence of adverse reactions between the two groups.Conclusions Low-dose and shortcourse hydrocortisone treatment for CAP-related sepsis can significantly reduce pleural effusion and pulmonary edema,and reduce the level of inflammatory cytokines,clinical effect more better.