盐酸贝那普利联合比索洛尔对高血压合并冠心病患者血脂及炎性因子水平影响

Effect of benazepril hydrochloride combined with bisoprolol on serum lipids and inflammatory factors in patients with hypertension and coronary heart disease

目的高血压是常见慢性病,可伴有心和脑等器官功能异常,也是心脑血管病最主要的危险因素。本研究探讨盐酸贝那普利联合比索洛尔对高血压合并冠心病患者血脂及炎性因子水平的影响。方法2017-01-01-2018-09-30选取宁陵县人民医院收治的92例高血压合并冠心病患者为研究对象,按照性别、年龄和病程组间均衡的原则分为对照组和观察组,各46例。所有患者均给予100mg阿司匹林肠溶片、单硝酸异山梨酯缓释片和瑞舒伐他汀钙治疗。在此基础上对照组给予盐酸贝那普利治疗,观察组给予盐酸贝那普利联合比索洛尔治疗。治疗后,比较两组患者三酰甘油(triacylglyceride,TG)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)等血脂水平及白介素-6(interleukin6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和超敏C反应蛋白(high sensitive C-reactive protein,CRP)等炎性因子水平。结果治疗后,观察组TC为(1.42±0.20)mmol/L,低于对照组的(1.75±0.46)mmol/L,t=4.462,P<0.001;TG为(4.02±0.45)mmol/L,低于对照组的(5.16±0.54)mmol/L,t=11.100,P<0.001;LDL-C为(2.35±0.36)mmol/L,低于对照组的(2.93±0.46)mmol/L,t=6.735,P<0.001;HDL-C水平为(1.70±0.20)mmol/L,高于对照组的(1.56±0.18)mmol/L,t=3.529,P=0.001。治疗后,观察组IL-6为(15.15±3.20)pg/mL,低于对照组的(19.38±3.15)pg/mL,t=6.389,P<0.001;TNF-α为(6.28±2.01)ng/L,低于对照组的(9.59±2.27)ng/L,t=7.404,P<0.001;CRP为(7.41±1.58)mg/L,低于对照组的(10.08±1.71)mg/L,t=7.778,P<0.001。结论高血压合并冠心病患者给予盐酸贝那普利与比索洛尔联合治疗,能够有效降低患者血脂水平,减轻机体炎性反应。

OBJECTIVE Hypertension is a common chronic disease,which can be accompanied by abnormal functions of heart,brain and other organs.It is also the most important risk factor for cardiovascular and cerebrovascular diseases.This study is to investigate the effects of benazepril hydrochloride combined with bisoprolol on blood lipid and inflammatory factors in patients with hypertension and coronary heart disease.METHODS From January 1,2017 to September 30,2018,a total of 92 patients with hypertension complicated with coronary heart disease were selected as the study subjects.According to the matching principle of gender,age and course of disease,the patients were divided into two groups.All patients were treated with 100 mg aspirin enteric-coated tablets isosorbide mononitrate sustained release tablets and rosuvastatin calcium.The control group was treated with benazepril hydrochloride,and the observation group was treated with benazepril hydrochloride combined with bisoprolol.After treatment,the levels of blood lipid levels such as tricylglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and interleukin were compared between the two groups.Levels of inflammatory factors such as interleukin6(IL-6),tumor necrosis factor-α(TNF-α)and high sensitive C-reactive protein(CRP)were measured.RESULTS After treatment,the TC of the observation group was(1.42±0.20)mmol/L,lower than that of the control group(1.75±0.46)mmol/L,t=4.462,P<0.001.The TG was(4.02±0.45)mmol/L,lower than that of the control group(5.16±0.54)mmol/L,t=11.100,P<0.001.The LDL-C was(2.35±0.36)mmol/L,lower than that of the control group(2.93±0.46)mmol/L,t=6.735,P<0.001.The level of HDL-C was(1.70±0.20)mmol/L,higher than that of the control group(1.56±0.18)mmol/L,t=3.529,P=0.001.After treatment,the level of IL-6 in the observation group was(15.15±3.20)pg/ml,lower than that in the control group(19.38±3.15)pg/ml,t=6.389,P<0.001.The level of TNF-αwas(6.28±2.01)ng/L,lower than that in the control group(9.59±2.27)ng/L,t=7.404,P<0.001.The CRP was(7.41±1.58)mg/L,lower than that in the control group(10.08±1.71)mg/L,t=7.778,P<0.001.CONCLUSION Benazepril hydrochloride combined with bisoprolol can effectively reduce blood lipid level and inflammatory reaction in patients with hypertension and coronary heart disease.