基于中西医临床病症特点的甲状腺癌动物模型分析

Analysis of Thyroid Carcinoma Animal Model Based on Clinical Characteristics of Chinese and Western Medicine

目的整理归纳甲状腺癌的造模方法和成模标准,为建立贴近中西医临床病证的甲状腺癌动物模型提供参考,促进临床诊疗的进展。方法分析、归纳中国知网、万方、Web of Science以及PubMed数据库中甲状腺癌动物模型的造模方法和模型特点,评判其优缺点,分析其与中西医临床病证特点的吻合度。结果甲状腺癌动物模型的造模方法较多,主要分为自发性、诱发性、基因工程与移植性模型四种,基因工程小鼠模型又包括转基因模型、基因替换模型、基因剔除模型及最新报道的限制性小鼠模型。其中,基因工程小鼠模型和移植性小鼠模型临床吻合度较高,自发性和诱发性肿瘤模型临床吻合度偏低。结论建立“中医证候”+“西医诊断标准”相符合的动物模型是未来研究甲状腺癌的重要方向之一。

Objective To summarize the modeling methods and standards of thyroid cancer,to provide reference for the establishment of thyroid cancer animal model close to the clinical syndrome of Chinese and Western medicine,and to promote the progress of clinical diagnosis and treatment.Methods The modeling methods and characteristics of animal models of thyroid cancer in CNKI,Wanfang,Web of Science and PubMed databases were analyzed and summarized.The advantages and disadvantages were evaluated,and the coincidence degree with the clinical characteristics of traditional Chinese and Western medicine was analyzed.Results There are many modeling methods for thyroid cancer animal models,which are mainly divided into four types:spontaneous,induced,genetic engineering and transplantation models.Genetic engineering mouse models include transgenic models,gene knockout models,gene replacement models and the latest reported restricted mouse models.Among them,the genetic engineering mouse model and the transplanted mouse model have a high clinical coincidence,and the spontaneous and induced tumor model have a low clinical coincidence.Conclusion It is one of the important directions for future research on thyroid cancer to establish an animal model consistent with"TCM syndrome"and"Western medicine diagnostic criteria".