中药材内在品质和外在性状结合的研究现状及对策

Research Status and Countermeasures on the Intrinsic Quality and Extrinsic Traits of Traditional Chinese Medicinal Materials

系统研究中药材质量评价方法,是完善中药材质量评价体系的内在需求,有利于中医临床用药及中药产业的健康发展。中药材内在品质评价方法从化学指纹图谱发展到中药质量标质物,从以化学成分为主要研究指标,发展为以化学成分与生物活性效价、化学成分与药效成分相结合的评价模式,历经了一元到多元的评价演变;中药材外在性状评价方法从“辨状论质”到智能感官的应用,历经从主观到客观的演变,弥补了客观数据缺失的评价不足。中药材“内外结合”评价的发展趋势符合中药整合质量观的创新发展思路。本文梳理了中药材内在品质与外在性状研究的发展沿革,系统阐述了“内外结合”评价的研究现状与发展趋势,从信息化角度提出了一些问题及初步对策,以期推进建立一套符合中医理论的,具有标准化、信息化特色的中药材质量评价体系。

Systematic research on the quality evaluation methods of Chinese medicinal materials is an intrinsic requirement,which is beneficial to the clinical application of traditional Chinese medicine and the sound development of traditional Chinese medicinal industry.The intrinsic quality evaluation methods of Chinese medicinal materials have developed from chemical fingerprint to quality marker of Chinese medicinal materials,and it represents that the evaluation mode has developed from chemical component as research index to the combination of chemical component and pharmacodynamic components,chemical component and biological activity.The extrinsic character evaluation method of Chinese medicinal materials from"Quality Evaluation Through Morphological Identification"to the application of intelligent sensory technology make up for the accumulation of objective data.The trend of quality evaluation of the intrinsic quality and extrinsic traits of Chinese herbal medicines conform to the innovation strategy called integrated quality control of TCMs.This paper reviews the development and evolution of the research on the intrinsic quality and extrinsic traits of Chinese herbal medicines,systematically expounds the research status and development trend of"intrinsic and extrinsic combination",and facilitate the establishment of quality evaluation system of Chinese herbal medicines with standardization and informatization characteristics in accordance with the theory of traditional Chinese medicine.