摘要
在多发性骨髓瘤的疾病进展和治疗过程中,约20%-40%的患者可以出现不同程度的周围神经病变,从而可能会影响化疗药物剂量及种类的应用。近年来的研究证实,自噬包括线粒体自噬作用贯穿于多发性骨髓瘤细胞增殖及周围神经病变的发生和治疗过程中。硼替佐米是治疗多发性骨髓瘤的一线用药,但其在临床应用中存在周围神经病变(Peripheral Neuropathy,PN)等副作用。中医结合临床辨证论治采用"温经化瘀"的思路,使用"温通经络、活血化瘀"的中药,对周围神经病变的治疗和缓解具有一定疗效。
In the progression and treatment of multiple myeloma,about 20%-40%of patients may have different degrees of peripheral neuropathy,which may affect the application of chemotherapy doses and types.Recent studies have confirmed that autophagy(including mitophagy)is involved in the proliferation of multiple myeloma cells and the occurrence and treatment of peripheral neuropathy.Bortezomib is the first-line drug for the treatment of multiple myeloma at present,but it has side effects such as peripheral neuropathy(PN)in clinical application.Traditional Chinese medicine(TCM)combined with clinical syndrome differentiation and treatment adopts the idea of"wenjinghuayu"and applies the traditional Chinese medicine with the effect of"wentongjingluo,huoxuehuayu",which has a certain clinical effect on its treatment and alleviation.
作者
孙润洁
何晓晴
崔兴
刘奎
崔思远
Sun Runjie;He Xiaoqing;Cui Xing;Liu Kui;Cui Siyuan(College of Chinese Mdeicine,Shandong University of Traditional Chinese medicine,Jinan,250011,China;Department of Hematology,Affiliated Hospital of Shandong University of Traditional Chinese medicine,Jinan,250011,China)
出处
《世界科学技术-中医药现代化》
CSCD
北大核心
2020年第7期2147-2153,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家自然科学基金委员会面上项目(81774080):黄芩汤调控线粒体自噬通路逆转肠粘膜屏障损伤、Th17/Treg失衡干预aGVHD的研究,负责人:崔兴
山东省人民政府泰山学者青年专家人才项目(tsqn201812145):中药干预多发性骨髓瘤基础自噬稳态的研究方法,负责人:崔兴
山东省科技厅重点研发计划(2019GSF108162):线粒体自噬在多发性骨髓瘤周围神经病变中的作用及温阳化瘀中药应用研究,负责人:崔兴
关键词
自噬
多发性骨髓瘤
周围神经病变
MTOR
线粒体
中药
Autophagy
Multiple Myeloma
Peripheral Neuropathy
mTOR
Mitochondrion
Traditional Chinese Medicine
