竞争性内源RNA调控在肝癌发生发展中的作用及中药干预相关研究现状

Research progress on competing endogenous RNAs regulation mechanism in the development of hepatocellular carcinoma and TCM interventions

阐述竞争性内源RNA(competing endogenous RNA,ceRNA)调控在肝癌发生发展中的作用机制,并探讨中药治疗肝癌与ceRNA调控作用的关系。ceRNA的调控以miRNA为核心,在miRNA反应元件(miRNA response element,MRE)的作用下,mRNA、假基因转录本、lncRNA、circRNA等竞争性地与miRNA结合,构成ceRNA调控网络。ceRNA的调控模式在肿瘤的发生发展、转移侵袭等过程中都发挥着重要的作用。目前有关ceRNA调控肝癌机制的研究还在探索阶段,其可提高靶向预测的准确性,有效筛选潜在治疗靶点和预后生物标志物。ceRNA调控机制也是中药治疗肝癌的重要调控方式,中药有效成分干预在肿瘤治疗方面有着非常广阔的前景,而基于ceRNA调控的中医药抗肿瘤机制研究也为肿瘤的诊断和治疗提供了新的研究方向。

The mechanism of competitive endogenous RNA(ceRNA)regulation in the occurrence and development of hepatocellular carcinoma(HCC)was reviewed and the relationship between TCM treatment of HCC and the regulation of ceRNA was discussed.The regulation of ceRNA takes miRNA as the core.Under the action of miRNA response element(MRE),Mrna,pseudogene transcripts,lncRNA,circRNA and others competitively combine with miRNA to form a ceRNA regulatory network.The regulation pattern of ceRNA plays an important role in the occurrence,development,metastasis and invasion of tumors.The research on the mechanism of ceRNA regulating HCC can improve the accuracy of targeted prediction and effectively screen potential therapeutic targets and prognostic biomarkers while at present it is still at the exploratory stage.The regulation mechanism of ceRNA is also an important regulation method of TCM in the treatment of HCC.The intervention of active ingredients of traditional Chinese medicine has a very broad prospect in the field of tumor treatment,and the study of the anti-tumor mechanism of traditional Chinese medicine based on ceRNA regulation also provides new research directions for the diagnosis and treatment of tumor.