子宫腺肌病发病机制和病理生理研究进展

Cracking the enigma of pathogenesis and pathophysiology of adenomyosis

子宫腺肌病是子宫内膜腺体和间质侵入子宫肌层形成弥漫性或局限性的病变,是妇科常见多发病,被普遍认为是一个“谜一样”的疾病,病因学及病理生理尚不明。子宫腺肌病的典型临床症状是月经量增多和进行性痛经,严重影响患者的生活质量,其治疗颇为棘手。根据10多年来的研究工作和其他发表的文献,综述子宫腺肌病的病因学、病理生理以及诊治,以期对子宫腺肌病的发病机制、病理生理研究、诊断和治疗的最新进展,以及亟待研究的今后方向,作一概括总结。

Adenomyosis,a condition resulting from the invasion of endometrial stromal and epithelial cells into the myometrium,is a common gynecological disease with an enigmatic pathogenesis and pathophysiology.Adenomyosis causes heavy menstrual blood loss and progressive dysmenorrhea,impacting negatively on the quality of life of the afflicted.Its clinical management is also a challenge.In this paper,we review the work mostly achieved by our team on this disease,hoping to summarize the pathogenesis,pathophysiology,diagnosis and treatment of adenomyosis,as well as the future direction of research.