郭光业教授从“湿、毒、虚”论治幽门螺杆菌经验

Professor Guo Guangye's Experience in Treating Helicobacter Pylori from the Perspective of“Dampness,Toxicity and Deficiency”

幽门螺杆菌(Helicobacter pylori,Hp)是导致胃黏膜炎性损伤的主要因素,目前根除Hp的方案面临细菌耐药等诸多挑战,郭光业教授从“病证结合”理念出发,认为Hp的中医特点关键在“湿”和“毒”,基本病机为脾虚湿滞,毒蕴络瘀,并据此组成健脾化湿、活血解毒方,临床应用疗效肯定。

Helicobacter pylori(Hp)infection is a primary factor that contributes to inflammatory damage of the gastric mucosa.However,the eradication of Hp is faced with numerous challenges such as bacterial resistance.To tackle this challenge,Professor Guo Guangye proposes the concept of“combination of disease and syndrome”and believes that traditional Chinese medicine(TCM)identifies the key characteristics of Hp as“dampness”and“toxin”.The basic pathogenesis involves spleen deficiency and dampness stagnation,leading to toxin accumulation in the collaterals.Based on this understanding,a TCM formula for invigorating the spleen and removing dampness,promoting blood circulation,and detoxifying is formulated.The clinical efficacy of this formula is positive.