肺炎三号辅治小儿肺炎肺脾气虚证的疗效及对免疫功能的影响

Curative Effect of Using Pneumonia No.3 in the Treatment of Infantile Pneumonia with Lung Spleen Qi Deficiency Syndrome and Its Influence on Immune Function

目的:探讨采用肺炎三号治疗小儿肺炎肺脾气虚证患儿的临床疗效及对患儿免疫功能的影响。方法:选择2018年9月~2020年9月张家口市妇幼保健院收治的小儿肺炎肺脾气虚证患儿180例作为研究对象,采用随机数字表法分为观察组(90例)及对照组(90例)。对照组采用常规西医对症治疗,观察组在对照组基础上加用肺炎三号进行辅助治疗。比较治疗前后两组患儿中医证候积分(咳少痰多、气短乏力、食少纳呆、低热、面色少华及大便稀溏等)、肺功能[肺容量(VC)、呼气高峰流量(PEF)、潮气量(V-T)]、免疫功能(CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))变化;比较两组患儿治疗有效率和不良反应情况。结果:治疗后观察组患儿咳少痰多、气短乏力、食少纳呆、低热、面色少华及大便稀溏等中医证候积分均低于对照组(P<0.05);观察组患儿VC、PEF、V-T水平均高于对照组(P<0.05);观察组患儿CD3^(+)、CD4^(+)及CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组(P<0.05);治疗后观察组治疗有效率高于对照组(P<0.05);治疗期间两组患儿不良发生率低差异无统计学意义(P>0.05)。结论:对于小儿肺炎肺脾气虚证患儿采取肺炎三号进行辅助治疗疗效确切,可改善患儿临床症状,提高患儿肺功能,调节其机体免疫力,且安全性较好。

Objective:To explore the clinical effect of using Pneumonia No.3 in treating children with pneumonia of lung and spleen Qi deficiency and its influence on immune function.Methods:A total of 180 children with pneumonia,lung and spleen-Qi deficiency syndrome,who were admitted to the hospital from September 2018 to September 2020,were selected as the research objects,and were randomly divided into a study group(90 cases)and a controlled group(90 cases)using a random number table.The controlled group was treated with conventional western medicine for symptomatic treatment.The study group added Pneumonia No.3 on the basis of the controlled group for adjuvant treatment.Compared the scores of TCM syndromes of the two groups of children before and after treatment(coughing less sputum,shortness of breath,fatigue,poor appetite,low fever,poor complexion,loose stools,etc.),lung function[lung volume(VC),peak expiratory flow(PEF),tidal volume(VT)],immune function(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+)).Compared the effective rate of treatment of the two groups of children after treatment.Counted and compared the adverse reactions of the two groups of children during the treatment period.Results:After treatment,the scores of TCM syndromes of children in the study group were lower than those in the controlled group,such as low cough and excessive phlegm,shortness of breath,fatigue,poor appetite and appetite,low fever,low complexion and loose stools(P<0.0 T).The levels of VC,PEF and V-T in the study group were higher than those in the controlled group(P<0.05).The CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)levels of children in the study group were higher than those of the controlled group,and the CD8^(+)levels were lower than those of the controlled group(P<0.05).After treatment,the effective rate of treatment in the study group was higher than that in the controlled group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups of children during the treatment period(P>0.05).Conclusion:For children with pneumonia,lung and spleen Qi deficiency syndrome,the adjuvant treatment of Pneumonia No.3 has a definite effect,which can improve the children’s clinical symptoms,improve the children’s lung function,regulate their immunity,and do not increase the risk of adverse reactions.