基于“异病同治”理论探讨当归芍药散经COX-2/PGF_(2α)轴治疗原发性痛经和阿尔茨海默病的作用机制

Investigating the Mechanism of Using Danggui Shaoyao Powder in Treating Primary Dysmenorrhea and Alzheimer’s Disease Via COX-2/PGF_(2α) Axis Based on “Treating Different Diseases with the Same Method” Theory

当归芍药散在临床上广泛用于治疗原发性痛经和阿尔茨海默病,本文欲从“异病同治”理论来阐释当归芍药散治疗这两种疾病的中西医机制。“异病同治”是中医学经典理论之一,不同疾病只要辨证相同,立法方药就可相同。原发性痛经和阿尔茨海默病,从中医角度来讲核心病机均为“肝郁脾虚”,即具有中医宏观层面相同的“证”,从现代医学角度来看,可能存在共同的生物学机制,即具有西医微观层面相同的“证”。本文通过对当归芍药散治疗阿尔茨海默病和原发性痛经的中西医理论基础及作用机制进行分析,表明其疏肝解郁的作用可能通过COX-2/PGF_(2α)轴而发挥关键作用,进一步阐述当归芍药散“异病同治”的科学内涵,为下一步实验研究提供理论依据。

Danggui Shaoyao Powder is widely used in the treatment of primary dysmenorrhea and Alzheimer’s disease.This article intends to explain the Chinese and western medicine mechanism of using Danggui Shaoyao Powder in the treatment of these two diseases from the theory of“Treating Different Disease with the Same Method”.“Treating Different Disease with the Same Method”is one of the classic theories of traditional Chinese medicine.As long as the different diseases are the same,the legislative prescriptions can be the same.Alzheimer’s disease and primary dysmenorrhea,from the perspective of Chinese medicine,the core pathogenesis is“Liver Depression and Spleen Deficiency”,that is,the same“certificate”of the macro level of Chinese medicine,from the perspective of modern medicine,there may be common organisms.The mechanism of learning,that is,the same“Certificate”at the micro level of western medicine.This paper analyzes the theoretical basis and mechanism of action of Chinese and western medicine for the treatment of Alzheimer’s disease and primary dysmenorrhea with Danggui Shaoyao Powder.It shows that the effect of soothing the liver and fortify the spleen may play a key role through the COX-2/PGF_(2α)axis,explain the scientific connotation of Danggui Shaoyao Powder.