补脾益心汤加减治疗脑梗死后血管性痴呆临床疗效及对患者血液流变学及认知功能的影响

Effect of Bupi Yixin Decoction on Clinical Efficacy,Hemorheology and Cognitive Function for Patients with Vascular Dementia after Cerebral Infarction

目的:分析补脾益心汤加减治疗对脑梗死后血管性痴呆(Vascular Dementia,VD)患者临床疗效、血液流变学及认知功能的影响。方法:选取2016年4月~2020年4月本院收治的124例脑梗死后VD患者,对其临床资料进行回顾性分析。根据治疗方式的差异将所有研究对象分为研究组(n=64)和对照组(n=60),对照组患者采用尼莫地平片+多奈哌齐片,研究组在对照组基础上增加补脾益心汤加减治疗。对比两组临床疗效、不良反应发生情况,观察两组治疗前后血液流变学指标、认知功能、痴呆程度及日常生活能力。结果:(1)研究组临床总有效率高于对照组(P<0.05)。(2)治疗后,两组血液流变学指标较疗前降低,且研究组各血液流变学指标改善程度均优于对照组(P<0.05)。(3)治疗后,研究组SDSVD评分较对照组低,MMSE评分较对照组高(P<0.05)。(4)治疗后研究组BI和ADL评分较对照组高(P<0.05)。(5)两组不良反应发生率比较无统计学意义(P>0.05)。结论:补脾益心汤加减治疗对脑梗死后VD患者临床疗效显著,可改善患者血液流变学,并提高其认知功能、日常生活能力,安全性高,值得推广。

Objective:To analyze the effect of Bupi Yixin Decoction on clinical efficacy,hemorheology and cognitive function for patients with vascular dementia(VD)after cerebral infarction.Methods:124 patients with VD after cerebral infarction admitted to this hospital from April 2016 to April 2020 were selected,their clinical data were retrospectively analyzed.According to the difference of treatment methods,all research subjects were divided into a study group(n=64)and a controlled group(n=60).Patients in the controlled group were given Nimodipine Tablets+Donepezil Tablets,and patients in the study group were supplemented with Bupi Yixin Decoction.The clinical efficacy and adverse reactions between the two groups were compared,and changes in hemorheology indexes,cognitive function,dementia degree,ability of daily living and immune function of patients in the two groups were observed before and after treatment.Results:(1)The total clinical effective rate of the study group was higher than that of the controlled group(P<0.05).(2)After treatment,the hemorheological indexes of the two groups were lower than those before treatment,and the improvement in the hemorheological indexes of the study group was better than that of the controlled group(P<0.05).(3)After treatment,the SDSVD score of the study group was lower than that of the controlled group,and the MMSE score was higher than that of the controlled group(P<0.05).(4)BI and ADL scores of the study group were higher than those of the controlled group after treatment(P<0.05).(5)After treatment,the levels of CDand CDin the study group were higher than those in the control group,and the level of CD/CDwas lower than that in the controlled group(P<0.05).(6)There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Bupi Yixin Decoction has a significant clinical effect for patients with VD after cerebral infarction.It can improve the patient’s hemorheology and improve their cognitive function and ability of daily living.It has high safety and is worthy of promotion.