新辅助化疗后手术时机选择对进展期胃癌患者预后疗效分析

Analysis of Prognosis of Patients with Advanced Gastric Cancer after Neoadjuvant Chemotherapy

目的分析新辅助化疗后手术时机选择对进展期胃癌患者预后的影响作用。方法选取广西桂东人民医院2014年1月—2017年12月收治的进展期胃癌患者90例作为观察对象,依据化疗后手术时机选择的不同进行分组,其中化疗后4周行手术作为观察组,化疗后8周行手术作为对照组,观察两组患者治疗效果、远期预后效果和术后并发症。结果观察组患者治疗总有效率97.78%明显大于对照组82.22%,组间差异有统计学意义(P<0.05);观察组复发率8.89%,生存率93.33%明显优于对照组的复发率24.44%和生存率77.78%,观察组患者远期预后效果明显优于对照组,组间差异有统计学意义(P<0.05);观察组术后并发症发生率6.67%,对照组术后并发症发生率8.89%,两组患者术后并发症发生率对比差异无统计学意义(P>0.05)。结论进展期胃癌患者在新辅助化疗后行手术治疗,其治疗效果可受到多种因素的影响,而本次研究结果证实,手术时机选择作为主要影响因素存在,化疗后早期手术有助于提升患者预后效果。

Objective To analyze the effect of timing of surgery after neoadjuvant chemotherapy on the prognosis of patients with advanced gastric cancer.Methods Ninety patients with advanced gastric cancer admitted to the hospital from January 2014 to December 2017 were enrolled in the study.They were divided according to the timing of surgery after chemotherapy.Four weeks after chemotherapy,surgery was performed as an observation group.Eight weeks of surgery was performed as a control group,and the treatment effect,long-term prognosis and postoperative complications of the two groups were observed.Results The total effective rate of the observation group was 97.78%,which was significantly higher than that of the control group(82.22%).The difference between the groups was significant(P<0.05).The recurrence rate of the observation group was 8.89%,and the survival rate was 93.33%,which was significantly better than the recurrence rate of the control group by 24.44%.The survival rate was 77.78%.The long-term prognosis of the observation group was significantly better than that of the control group.The difference between the two groups was significant(P<0.05).The postoperative complication rate was 6.67%in the observation group and 8.89%in the control group.There was no significant difference in the incidence of postoperative complications between the two groups(P>0.05).Conclusion Patients with advanced stage of injury undergo surgery after neoadjuvant chemotherapy.The therapeutic effect can be affected by many factors.The results of this study confirm that the timing of surgery is the main influencing factor.Early surgery after chemotherapy can help to improve patient prognosis.