间苯三酚用于经尿道膀胱镜下输尿管支架管取出术的临床疗效

Clinical applications of phloroglucinol in the removal of ureteral stents under transurethral cystoscopy

目的探讨间苯三酚用于经尿道膀胱镜下输尿管支架管取出术中的应用价值。方法选取2018-06至2020-10海警医院收治的上尿路结石术后患者300例,均为男性,行经尿道膀胱镜下输尿管支架管取出术,根据患者意愿分为常规组(100例)和观察组(200例),两组均给予常规的利多卡因胶浆尿道黏膜表面麻醉,在此基础上观察组术前15 min静脉注射间苯三酚80 mg。观察两组术中的疼痛评分、尿道黏膜损伤血尿情况及不良反应。结果观察组无药物不良反应,观察组术中的疼痛比常规组降低,观察组轻度疼痛88.9%,常规组轻度疼痛为54.6%,差异有统计学意义(P=0.036)。观察组患者的血尿次数少于常规组患者的血尿次数,差异有统计学意义(P=0.003)。两组患者年龄、输尿管支架管部位、留置时间差异无统计学意义。结论间苯三酚联合利多卡因胶浆用于经尿道膀胱镜输尿管支架管取出术,可以缓解患者疼痛和尿道损伤,无不良反应,值得在临床推广应用。

Objective To investigate the applicability of phloroglucinol in transurethral cystoscopic removal of ureteral stents.Methods A random sample of 300 postoperative patients with upper urinary calculi treated in our hospital between June 2018 and October 2020 was collected.All these subjects were male,who had had their ureteral stents removed under transurethral cystoscopy in our hospital.They were randomly divided into the conventional group(n=100)and the observation group(n=200).Both groups received conventional lidocaine mucilage urethral mucosal surface anesthesia,but the observation group was also intravenously injected with phloroglucinol 80 mg 15 minutes preoperatively.The pain score,urethral mucosal injury,hematuria and adverse reactions were observed.Results There was no adverse drug reaction in the observation group.The level of intraoperative pain of the observation group was significantly lower than that of the conventional group.The incidence of mild pain was 88.9%in the observation group,but 54.6%in the conventional group,so the difference between the two groups was statistically significant(P=0.036).Hematuria was significantly less frequent in the observation group than in the conventional group,and the difference between the two groups was statistically significant(P=0.003).There was no significant difference between the two groups in age,locations of ureteral stents,or indwelling time.Conclusions Phloroglucinol combined with lidocaine mucilage during transurethral cystoscopic ureteral stent removal can significantly alleviate patients’pain and urethral injury without any adverse reactions,so this approach should be made more accessible.