基于数据挖掘探讨药食同源类中药在治疗感冒后咳嗽中的用药规律

Based on data mining to explore the medication rule of traditional Chinese medicine with the same origin of medicine and food in the treatment of cough after cold

目的:探讨近10年来药食同源类中药防治感冒后咳嗽的应用及配伍规律。方法:检索4个中文数据库(CNKI、WANFANG DATA、VIP、CBM),筛选2012—2021年治疗感冒后咳嗽的临床文献,建立方药数据库。通过Microsoft Excel 2019、SPSS Modeler 18.0及SPSS Statistics 24.0软件对处方药物进行关联规则、复杂网络、系统聚类和因子分析。结果:纳入的417首处方涉及257味中药,较常见的药食同源中药为甘草、桔梗、苦杏仁、陈皮、茯苓、生姜等;关联规则分析得到34对核心药组;复杂网络核心处方由止嗽散组成;聚类分析得到8个药物组合;因子分析提取出14个公因子。结论:药食同源类中药的运用符合中医学“治未病”的思想,可以应用于预防感冒后咳嗽。

Objective:To explo re the application and compatibility of homologous traditional Chinese medicine in the prevention and treatment of cough after cold in recent 10 years.Methods:Four Chinese databases(CNKI,WANFANG DATA,VIP,CBM)were searched,and the clinical literature on the treatment of cough after cold in 2012-2021 was screened,and the prescription database was established.The association rules,complex network,systematic clustering and factor analysis of prescription drugs were carried out by MicrosoftExcel2019,SPSS Modeler18.0 and SPSSS tatistics24.0 software.Results:The 417 prescriptions included involved 257 traditional Chinese medicines,the most common of which were licorice,Platycodon grandiflorum,bitter almond,tangerine peel,Poria cocos,ginger,etc;34 pairs of core drug groups were obtained by association rule analysis;complex network core prescriptions were composed of Zhisou powder;8 drug combinations were obtained by cluster analysis;14 common factors were extracted by factor analysis.Conclusion:The use of traditional Chinese medicine with the same origin of medicine and food is in line with the idea of"treating non-disease"in traditional Chinese medicine,and can be used to prevent cough after a cold.