益糖康对初诊气阴两虚型T2DM患者胰岛β细胞功能及炎症因子影响

Effect of Yitangkang(益糖康)for Newly Diagnosed Type 2 Diabetes Patients with Deficiency ofBoth Qi and Yin and the Influence on Pancreatic β-cell Function and Inflammatory Factors

目的观察中药复方益糖康对气阴两虚型2型糖尿病(T2DM)患者胰岛β细胞功能及炎症因子的影响。方法选取符合纳入标准的90例初诊断气阴两虚证T2DM患者,随机分成对照组和观察组,各45例。对照组予以糖尿病教育、饮食、运动治疗及二甲双胍治疗,观察组患者在对照组基础上给予中药复方益糖康,观察治疗前后两组患者的血糖水平[空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)]、胰岛β细胞功能[空腹C肽(FCP)、餐后2 h C肽(2 h PCP)]、胰岛β细胞功能指数(HOMA-β)、胰岛素抵抗指数(HOMA-IR)、中医证候积分、血清炎症因子[C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)]变化情况。结果治疗2周后,两组患者血糖水平较治疗前均显著下降(P<0.05),但组间比较差异无统计学意义(P>0.05);观察组患者血糖水平、HbA1c、FCP、2 h CP、HOMA-IR、CRP、IL-6、TNF-α均低于对照组(P<0.05),而HOMA-β高于对照组(P<0.05);观察组中医证候积分明显改善(P<0.05)。结论中药复方益糖康能够改善气阴两虚型T2DM患者的胰岛β细胞功能,增加胰岛素敏感性,减轻胰岛素抵抗,增强血糖控制效果,并可以一定程度的改善患者的乏力、手足心热、酸胀沉重等临床表现。

Objective To observe the effect of Yitangkang(益糖康),a traditional Chinese medicine compound,on pancreaticβ-cell function and inflammatory factors in patients with type 2 diabetes(T2 DM)with deficiency of Qi and Yin.Methods A total of 90 patients with T2 DM who were initially diagnosed with syndrome of Qi and Yin deficiency who met the inclusion criteria were selected and randomly divided into a control group and an observation group with 45 cases in each group.The control group was given diabetes education,diet,exercise therapy and metformin treatment.The observation group was given Chinese medicine compound Yitangkang on the basis of the control group.The blood glucose levels of the two groups were observed before and after treatment[fasting plasma glucose(FPG),2-hour postprandial glucose(2 h PG),glycated hemoglobin(HbA1 c)],isletβ-cell function[fasting C peptide(FCP),2-hour postprandial c peptide(2 h PCP)],isletβ-cell function index(HOMA-β),insulin resistance index(HOMA-IR),TCM syndrome integral,serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor(TNF-α)]changes.Results After 2 weeks of treatment,the blood glucose levels of the two groups were significantly lower than before treatment(P<0.05),but there was no difference between the groups(P>0.05);the blood glucose levels,HbA1 c,FCP,2 h CP,HOMA-IR,CRP,IL-6,and TNF-αwere all lower than the control group(P<0.05),while HOMA-βwas higher than the control group(P<0.05);the TCM syndrome integral of the observation group were significantly improved(P<0.05).Conclusion The traditional Chinese medicine compound Yitangkang can improve the pancreaticβ-cell function of patients with T2 DM with deficiency of both Qi and Yin,increase insulin sensitivity,reduce insulin resistance,enhance blood sugar control,and can improve the clinical manifestations,such as fatigue,hand and foot heat,acid heaviness.