中药有效成分及方剂多靶点调控治疗帕金森病研究进展

Research Progress on Prevention and Treatment of Parkinson’s Disease by TCM Active Components and Prescription

帕金森病(PD)的基本病理特征是黑质-纹状体多巴胺能神经元的丢失及路易小体的形成,最终造成PD特有的运动功能障碍。目前治疗帕金森病的西药种类较多,但每一类药物都有不少不良反应。大量研究表明中药有效成分及方剂在治疗PD方面具有独特的优势。该文从中药有效成分及方剂抑制黑质多巴胺能神经元凋亡、保护线粒体功能、增加多巴胺释放或保护多巴胺能神经元、抑制神经元免疫与炎症反应及改变氧化应激等方面综述了近年来国内外期刊报道的中药有效成分及方剂防治PD的研究进展,以为PD的新药及方剂研发提供理论依据。

The basic pathological features of Parkinson’s disease are the loss of dopaminergic neurons in the substantia nigra stratum and the formation of the lewy bodies,which eventually lead to the motor dysfunction peculiar to PD.At present,there are many kinds of western medicine for Parkinson’s disease,but each kind of medicine has many adverse reactions.A large of studies have shown that Chinese medicine effective component and has the unique superiority in the treatment of PD prescriptions in the paper,from the traditional Chinese medicine effective component and inhibition of substantia nigra dopamine prescriptions glue can neurons apoptosis,mitochondrial function,increase dopamine release or protect dopaminergic neurons,inhibition of immune and inflammatory research and the change of oxidative stress were reviewed at home and abroad in recent years,the research progress of prevention and control of traditional Chinese medicine effective component and prescription of PD,PD provide theoretical basis for the new drug and prescription research and development.