米非司酮联合血府逐瘀颗粒治疗子宫肌瘤临床疗效

Clinical Effect of Mifepristone Combined with Xuefu Zhuyu Granule(血府逐瘀颗粒)in Treatment of Hysteromyoma

目的探讨米非司酮联合血府逐瘀颗粒治疗子宫肌瘤的临床效果。方法将2019年1月—2020年10月在丹东市第一医院妇科治疗的116例子宫肌瘤患者随机分为两组,每组各58例,对照组使用米非司酮治疗,观察组使用米非司酮联合血府逐瘀颗粒治疗,对比两组的临床疗效、中医证候积分变化、血清激素水平变化、子宫体积及子宫肌瘤体积变化、不良反应。结果观察组治疗有效率为94.83%(55/58),明显高于对照组的74.14%(43/58)(P<0.05);观察组治疗后下腹坠胀、下腹包块、经血黏稠、月经量多、腰膝酸软、乳房胀痛等中医证候积分明显低于对照组(P<0.05);观察组治疗后黄体生成激素(LH)、卵泡生成激素(FSH)、孕酮(P)、雌二醇(E_(2))水平均明显低于对照组(P<0.05);观察组治疗后子宫体积、子宫肌瘤体积均明显小于对照组(P<0.05);观察组头晕、恶心呕吐、腹痛、乏力等不良反应发生率与对照组相比差异无统计学意义(P>0.05)。结论米非司酮联合血府逐瘀颗粒治疗子宫肌瘤的临床效果显著,能有效减轻中医证候,调节内分泌水平,缩小子宫及子宫肌瘤体积,且不良反应发生率低,具有积极的临床意义。

Objective To investigate the clinical effect of mifepristone combined with Xuefu Zhuyu Granule(血府逐瘀颗粒)in the treatment of uterine fibroids.Methods A total of 116 patients with hysteromyoma treated in the hospital from January 2019 to October 2020 were randomly divided into two groups,58 cases in each group.The control group was treated with mifepristone,and the observation group was treated with mifepristone combined with Xuefu Zhuyu Granule.The clinical efficacy,changes of TCM syndrome score,changes of serum hormone level,changes of uterine volume and hysteromyoma volume,and no adverse reactions were compared between the two groups.Results The effective rate of the observation group was 94.83%(55/58),which was significantly higher than 74.14%(43/58)of the control group(P<0.05).After treatment,the TCM syndrome scores of the observation group were significantly lower than those of the control group(P<0.05).The levels of LH,FSH,P and E_(2)in the observation group were significantly lower than those of the control group(P<0.05).After treatment,the uterine volume and hysteromyoma volume of the observation group were significantly smaller than those of the control group(P<0.05).The incidence of adverse reactions such as dizziness,nausea and vomiting,abdominal pain and fatigue of the observation group had no significant difference compared with that of the control group(P>0.05).Conclusion The clinical effect of mifepristone combined with Xuefu Zhuyu Granule in the treatment of hysteromyoma is significant,which can effectively reduce the TCM syndrome,regulate the endocrine level,reduce the volume of uterus and hysteromyoma,and has a positive clinical significance with low incidence of adverse reactions.