青黛灌肠液灌肠联合美沙拉嗪治疗溃疡性结肠炎对患者症状改善和黏膜愈合的疗效观察

Effect of Qingdai Enema Solution Combined with Mesalazine on Symptom Improvement and Mucosal Healing in Patients with Ulcerative Colitis

目的观察青黛灌肠液灌肠联合美沙拉嗪治疗溃疡性结肠炎对患者症状改善和黏膜愈合的疗效,为临床治疗提供参考。方法选取该院(2018年1月—2019年12月)收治的溃疡性结肠炎患者60例,根据治疗方法分为对照组(30例)和观察组(30例)。对照组给予美沙拉嗪口服联合美沙拉嗪灌肠液灌肠治疗,观察组给予美沙拉嗪口服联合青黛灌肠液灌肠治疗,两组均连续治疗8周。记录两组治疗前后症状评分、内镜评分、组织学改变评分及血沉水平变化,并统计两组临床治疗总有效率和治疗期间的不良反应率。结果治疗后,两组排便次数评分、便血评分、腹痛评分、内镜评分、组织学改变评分较治疗前下降,观察组排便次数评分、腹痛评分、内镜评分低于对照组,但便血评分、组织学改变评分与对照组比较,差异不具有统计学意义(P>0.05)。治疗后,两组血沉水平较治疗前下降,观察组血沉水平低于对照组(P<0.05)。治疗后,观察组和对照组的总有效率分别为96.67%(29/30)和80.00%(24/30),差异有统计学意义(P<0.05)。治疗期间,观察组和对照组的不良反应发生率分别为6.67%(1/30)和10.00%(3/30),差异不具有统计学意义(P>0.05)。结论青黛灌肠液灌肠联合美沙拉嗪治疗溃疡性结肠炎可改善症状,促进黏膜愈合,降低血沉水平,提高疗效。

Objective To observe the effect of Qingdai enema combined with mesalazine in the treatment of ulcerative colitis on the improvement of symptoms and mucosal healing and provide reference for clinical treatment.Methods Sixty patients with ulcerative colitis treated in our hospital(January 2018~December 2019)were selected and divided into control group(30 cases)and observation group(30 cases)according to the treatment method.The control group was treated with mesalazine orally combined with mesalazine enema solution and the observation group with mesalazine orally combined with Qingdai enema solution for 8 weeks.The symptom score,endoscopic score,histological change score and ESR level changes were recorded before and after treatment and the total effective rate of clinical treatment and the adverse reaction rate during treatment in two groups were counted.Results After treatment,the scores of defecation times,hematochezia,abdominal pain,endoscopy and histological changes in the two groups were decreased compared with those before treatment.The scores of defecation times,abdominal pain and endoscopy in the observation group were lower than those in the control group,but the scores of hematochezia and histological changes were not statistically significant(P>0.05).After treatment,the ESR level in the two groups was decreased compared with that before treatment,and the ESR level in the observation group was lower than that in the control group(P<0.05).After treatment,the total effective rate of the observation group and the control group was 96.67%(29/30)and 80.00%(24/30),respectively,and the difference was statistically significant(P<0.05).During the treatment period,the incidence of adverse reactions in the observation group and the control group was 6.67%(1/30)and 10.00%(3/30),respectively,and the difference was not statistically significant(P>0.05).Conclusion Qingdai enema combined with mesalazine in the treatment of ulcerative colitis can improve symptoms,promote mucosal healing,reduce the erythrocyte sedimentation rate,and improve the curative effect.