摘要
目的观察黄芪通络方对气阴两虚兼血瘀型糖尿病周围神经病变患者的临床疗效和氧化应激水平的影响。方法选取该院气阴两虚兼血瘀型糖尿病周围神经病变患者80例,随机分为对照组和治疗组,每组各40例,两组患者均给予糖尿病常规基础治疗,对照组在基础治疗上加用甲钴胺片,治疗组在对照组治疗的基础上,加用黄芪通络方,共观察8周。观察患者治疗前后的总有效率及空腹血糖(FBG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c);血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL);腓总神经运动传导速度(MNCV)、腓总神经感觉传导速度(SNCV);丙二醛(MDA)、超氧化物歧化酶(SOD)水平。结果治疗后综合疗效比较,治疗组总有效率为87.50%,对照组总有效率为60.00%,治疗组优于对照组(P<0.05);黄芪通络方治疗组患者治疗后TC、TG、HDL、MNCV、SNCV、MDA、SOD水平变化,优于对照组(P<0.05)。结论黄芪通络方可以改善气阴两虚兼血瘀型糖尿病周围神经病变患者脂代谢水平,提高神经传导速度,降低氧化应激水平,临床疗效显著。
Objective To observe the effect of Huangqi Tongluo Recipe on the clinical efficacy and oxidative stress level of patients with diabetic peripheral neuropathy(DPN)due to deficiency of both Qi and Yin and blood stasis.Methods Eighty DPN patients conforming to the diagnostic criteria were randomly divided into treatment group(Huangqi Tongluo Recipe,40 patients)and control group(Methyldiamine,40 patients).Combined with routine treatments(patients education,controls for blood glucose,blood pressure and blood lipid),the control group was given Methyldiamine while Huangqi Tongluo Recipe group was given Huangqi Tongluo Recipe and Methyldiamine for 8 weeks.The alterations of the total effective rate,blood glucose,blood lipid,motor conduction velocity of common peroneal nerve(MNCV),sensory conduction velocity of common peroneal nerve(SNCV),malondialdehyde(MDA),superoxide dismutase(SOD)were compared.Results The general effective rate in Huangqi Tongluo Recipe(87.50%)was 27.50%higher than that in control group(60.00%,P<0.05).The levels of total cholesterol(TC),triglycerides(TG),MNCV,SNCV and MDA in Huangqi Tongluo Recipe group were significantly lower than those in the control group(P<0.05).The levels of high density lipoprotein(HDL)and SOD in Huangqi Tongluo Recipe group were significantly higher than those in the control group(P<0.05).Conclusion Huangqi Tongluo Decoction can improve blood lipid,increasing nerve conduction velocity and reducing oxidative stress in patients with DPN.
作者
常健菲
吴开明
刘春颖
王顺
CHANG Jianfei;WU Kaiming;LIU Chunying;WANG Shun(Heilongjiang Academy of Traditional Chinese Medical Sciences,Harbin 150036,Heilongjiang,China;The First Affiliated Hospital Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China)
出处
《辽宁中医杂志》
CAS
2020年第10期107-109,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
黑龙江省中医药管理局课题(ZHY18-054)
黑龙江省博士后课题(201121)
关键词
糖尿病周围神经病变
黄芪通络方
丙二醛
超氧化物歧化酶
临床研究
diabetic peripheral neuropathy
Huangqi Tongluo Recipe
malondialdehyde(MDA)
superoxide dismutase(SOD)
clinical research