丹参川芎嗪注射液联合胺碘酮对急性心肌梗死并发房颤患者血清癌胚抗原CA-125水平影响研究

Study on Effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection Combined with Amiodarone on Serum Carcinoembryonic Antigen CA-125 Level of Patients with Acute Myocardial Infarction Complicated with Atrial Fibrillation

目的探讨丹参川芎嗪注射液联合胺碘酮对急性心肌梗死并发房颤患者血清癌胚抗原CA-125水平的影响。方法选取本院收治的急性心肌梗死并发房颤患者148例,按随机数字表法分组,对照组74例予以胺碘酮治疗,研究组74例在对照组基础上予以丹参川芎嗪注射液液治疗,比较两组间血清CA125、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)水平、血清N末端脑钠肽前体(NT-pro-BNP)、同型半胱氨酸(Hcy)、髓过氧化物酶(MPO)水平,临床疗效、不良反应发生率及缺血事件发生率。结果对照组有效率[82.43%(61/74)]低于研究组[93.24%(69/74)],具有统计学意义(P<0.05);与对照组比较,研究组治疗后血清CA125、CRP、TNF-α水平较低,治疗后血清NT-pro-BNP、Hcy、MPO水平较低,具有统计学意义(P<0.05);研究组不良反应发生率[5.40%(4/74)]低于对照组[17.57%(13/74)],具有统计学意义(P<0.05);研究组心力衰竭、房颤复发、心源性死亡的发生率低于对照组,具有统计学意义(P<0.05)。结论丹参川芎嗪注射液联合胺碘酮能有效降低急性心肌梗死并发房颤患者血清CA-125及相关细胞因子水平,提高治疗效果,降低不良反应发生率,并有效改善患者预后。

Objective To investigate the effect of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with amiodarone on serum carcinoembryonic antigen 125(CA-125)level in patients with acute myocardial infarction complicated with atrial fibrillation.Methods A total of 148 patients with acute myocardial infarction complicated with atrial fibrillation in our hospital were selected and divided into two groups.Seventy-four cases in the control group were treated with amiodarone and those in the experiment group were treated with Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on the basis of control group.The levels of serum CA125,C reactive protein(CRP),tumor necrosis factor-(TNF-α),levels of serum N N-terminal pro brain natriuretic peptide(NT-pro-BNP),homocysteine(Hcy)and myeloperoxidase(MPO),the clinical efficacy,adverse reaction rate and ischemic event rate were compared.Results The effective rate in the control group(82.43%,61/74)was lower than that in the experiment group(93.24%,69/74),and the difference was statistically significant(P<0.05).Compared with the control group,serum levels of CA125,CRP and TNF-αwere lower after treatment in the experiment group and serum levels of NT-pro-BNP,Hcy and MPO were lower after treatment(P<0.05).The incidence of adverse reactions in the experiment group(5.40%,4/74)was lower than that in the control group(17.57%,13/74),and the difference was statistically significant(P<0.05).The incidence of heart failure,atrial fibrillation recurrence and cardiac death in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection combined with amiodarone can effectively reduce serum levels of CA-125 and related cytokine in patients with acute myocardial infarction complicated with atrial fibrillation,improve the treatment effect,reduce the incidence of adverse reactions,and effectively improve the prognosis of patients.