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清肺排毒汤治疗新型冠状病毒肺炎的方药理论研究 被引量:17

Theoretical Study on Corona Virus Disease 2019 Treated by Qingfei Paidu Decoction
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摘要 国家发布的新冠肺炎诊疗方案(第六版)提出了清肺排毒汤可用于治疗确诊病例的各个类型,中药复方清肺排毒汤治疗新冠肺炎的有效性已经在前期的临床实践中得到初步证实,文章从《伤寒杂病论》经方及现代药理学的角度对清肺排毒汤治疗新冠肺炎进行了方药理论研究。清肺排毒汤是麻杏石甘汤、五苓散、小柴胡汤、射干麻黄汤和橘枳姜汤等多个经方的巧妙融合;麻杏石甘汤和五苓散相合,既祛寒闭又利小便祛湿,从多途径祛除新冠肺炎之"寒湿疫毒",尚可清泄"寒湿疫毒"入里之郁热;"寒湿疫毒"闭肺,痰饮阻肺,气机不畅,又合用射干麻黄汤及橘枳姜汤理气宽胸、化痰祛饮;小柴胡汤协调气机升降,疏利三焦,调达上下,宣通内外,既防"寒湿疫毒"入里,又调肝和胃,顾护人体消化功能;此外,加用藿香芳香化湿和中,山药生津益肺、补脾养胃;全方针对新冠肺炎"寒湿疫毒"的病因病机特点,从多途径祛除"寒湿疫毒",宣畅三焦,既清除肺部疫毒,又给邪气以出路,同时兼顾正气,标本同治,故临床疗效甚佳。此外,药理学研究表明,各个经方具有抗病毒、抗炎、解热、调节免疫等多种药理学作用;清肺排毒汤复方可以通过多成分、多靶标对机体起到整体调控作用,它通过调控相关蛋白及信号通路,起到抗病毒、平衡免疫、消除炎症的作用,这些是清肺排毒汤治疗新冠肺炎可能的药理学作用机制。 Thecorona virus disease 2019(COVID-19)treatment plan(sixth edition)has been proposed by the state.It put forward that Qingfei Paidu Decoction can be used to treat various types of confirmed cases.The effect of Qingfei Paidu Decoctionon COVID-19 has been preliminarily confirmed in the early clinical practice.We planed to study the theory of Qingfei Paidu Decoctiontreating COVID-19 from the perspective of Treatise On Febrile Diseases and Miscellaneous Diseases and modern pharmacology.Qingfei Paidu Decoction is a skillful fusion of several prescriptions,such as Maxing Shigan Decoction,Wuling Decoction,Xiaochaihu Decoction,Shegan Mahuang Decoction and Juzhijiang Decoction,etc.The combination of Maxing Shigan Decoction and Wuling Powder can dispel cold and promote urination,relieve the"damp toxin"of COVID-19 from multiple ways and clear away the stagnant heat of"epidemic virus"."Epidemic toxin"in the lung could make phlegm and water obstruct the lung,and the Qi can not move normallyand thus using Shegan Mahuang Decoction and Juzhijiang Decoction together to regulate Qi,dissipate phlegm and dispel water.Xiaochaihu Decoction can coordinate the rise and fall of Qi,dredge and adjust Sanjiao up and down.It can prevent"epidemic virus"from entering,regulate the liver and stomach,and protect the digestive function of human body.In addition,it adds Huoxiang(Agastache rugosus)to resolve the dampness and harmonize the middel.Shanyao(Chinese yam)can promote body fluid,benefit lung,invigorate spleen and nourish stomach.In view of the characteristics of the etiology and pathogenesis of COVID-19,Qingfei Paidu Decoction has many ways to remove the"epidemic toxin",and pays attention to the smooth flow of Qi and the maintenance of healthy Qi,and so the clinical curative effect is very good.In addition,Qingfei Paidu Decoctioncan play a role in regulating the body through multiple components and multiple pathways.It has many pharmacological functions,such as antivirus,anti-inflammatory,antipyreticand immunoregulation.These pharmacological functions of Qingfei Paidu Decoction may be mechanisms in treating COIVD-19.
作者 姚佳 史晓燕 陈秋 凡思敏 杨仁旭 彭波 YAO Jia;SHI Xiaoyan;CHEN Qiu;FAN Simin;YANG Renxu;PENG Bo(Clinical Medical College of Chengdu University of TCM,Chengdu 610072,Sichuan,China;Affiliated Hospital of Chengdu University of TCM,Chengdu 610072,Sichuan,China)
出处 《辽宁中医杂志》 CAS 2020年第5期94-98,共5页 Liaoning Journal of Traditional Chinese Medicine
基金 中医药传承与创新“百千万”人才工程:全国老中医药专家学术经验继承项目(国中医药人教发[2017]29号) 成都中医药大学“杏林学者”计划(XGZX2003) 四川省科技厅项目(2020YFS0013)
关键词 新冠肺炎 清肺排毒汤 中医理论 寒湿疫毒 COIVD-19 Qingfei Paidu Decoction TCMtheory cold and damp epidemic disease
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