532例早期先兆流产患者安胎结局与甲状腺功能状况的相关性探讨

Correlation between Fetal Outcomes and Thyroid Function in 532 Patients with Early Threatened Abortion

目的:分析早期先兆流产患者安胎结局与甲状腺功能的相关性,初步探讨甲状腺功能状况对早期先兆流产患者安胎结局的影响,为早期干预甲状腺功能及用药提供数据支撑。方法:回顾性研究532例早期先兆流产患者,分为安胎成功组(402例)及安胎失败组(130例),通过测定甲状腺功能(TSH),和随访患者安胎结局,评估甲状腺功能状况与安胎结局的相关性。结果:安胎成功组共402例,105例正服用优甲乐,182例促甲状腺激素(TSH)<2.5 m IU/L,42例TSH 2.5~5 m IU/L,3例TSH≥10 m IU/L;安胎失败组共130例,28例正服用优甲乐,48例TSH<2.5 m IU/L,20例TSH2.5~5 m IU/L,4例TSH≥10 m IU/L。结论:随着促甲状腺激素(TSH)值升高,安胎成功率逐渐降低,安胎失败率逐渐上升;是否使用优甲乐对安胎结局无明显影响。

Objective:To analyze the correlation between the outcome of anaesthesia and thyroid function in patients with early threatened abortion and explore the effect of thyroid function on the outcome of early pregnancy with threatened abortion and provide the data support for the early intervention of thyroid function and medication.Methods:A retrospective study of 532 patients with early threatened abortion was divided into a successful fetus(402 cases)and a failure group(130 cases).By measuring thyroid function(TSH)and following the patient’s fetus outcome,the correlation between thyroid function status and tocolytic outcomes was analyzed.Results:A total of 402 successful cases of tocolysis were performed,105 cases were taking euthyroid,182 cases of thyrotropin(TSH)<2.5 m IU/L,42 cases of TSH 2.5-5 m IU/L,3 cases of TSH≥10 m IU/L.A total of 130 patients in the failure group were enrolled in the study.Twenty-eight patients took eugenics,48 patients had TSH<2.5 m IU/L,20 patients had TSH 2.5-5 m IU/L,and 4 patients had TSH≥10 m IU/L.Conclusion:With the increase of thyroid stimulating hormone(TSH)value,the success rate of fetus is gradually reduced,and the failure rate of fetus is gradually increasing.Whether or not using euthanasia has no significant effect on the outcome of fetus.