同型半胱氨酸和胱抑素C水平与不同性别冠心病的相关性分析

Correlation between Homocysteine and Cystatin C Levels and Coronary Heart Disease of Different Genders

目的:分析冠心病患者性别与同型半胱氨酸、胱抑素C的关联性与影响。方法:选取2017年1月-2019年12月我院收治的冠心病患者126例作为观察组,抽选同期我院收治非冠心病患者100例作为对照组,均接受同型半胱氨酸、胱抑素C、尿酸、低密度脂蛋白等相关检查,对比两组指标差异,分析不同性别冠心病患者指标差异情况。结果:观察组患者同型半胱氨酸、胱抑素C、尿酸、低密度脂蛋白水平均明显高于对照组(P<0.05)。观察组男性和女性的相应检查指标均明显高于对照组患者(P<0.05)。观察组男性患者的同型半胱氨酸、胱抑素C水平均明显高于女性冠心病患者,差异有统计学意义(P<0.05)。相关因素分析发现,同型半胱氨酸、胱抑素C均为冠心病的危险因素,而吸烟史则为男性患者独立危险因素,尿酸过高成为女性患者发生冠心病的独立危险因素。结论:同型半胱氨酸、胱抑素C水平与冠心病发生密切相关,临床应予以关注。

Objective:To analyze the correlation and influence of sex with homocysteine and cystatin C in patients with coronary heart disease.Methods:126 patients with coronary heart disease admitted to our hospital from January2017 to December 2019 were selected as the observation group,and 100 patients with non-coronary heart disease admitted to our hospital during the same period were selected as the control group,all receiving homocysteine and cystatin C,uric acid,low-density lipoprotein and other related tests,compare the differences between the two groups of indicators,and analyze the differences in indicators of patients with coronary heart disease of different genders.Results:The levels of homocysteine,cystatin C,uric acid and low-density lipoprotein in the observation group were significantly higher than those in the control group(P<0.05). The corresponding examination indexes of men and women in the observation group were significantly higher than those in the control group(P<0.05). The homocysteine and cystatin C levels of male patients in the observation group were significantly higher than those of female patients with coronary heart disease,the difference was statistically significant(P<0.05). Analysis of related factors found that homocysteine and cystatin C are both risk factors for coronary heart disease,and smoking history is an independent risk factor for male patients. Hyperuricemia has become an independent risk factor for coronary heart disease in female patients.Conclusion:The levels of homocysteine and cystatin C are closely related to the occurrence of coronary heart disease and should be paid attention to in clinic.