摘要
尿8-羟基脱氧鸟苷(8-OHdG)是反映机体氧化应激及DNA氧化损伤的标志物。人一生有80%~90%的时间在室内度过,室内空气质量直接关系到人体健康。本文介绍了不同人口特征、生活方式、职业暴露、健康状态的人群尿8-OHdG水平,阐述了影响人群尿8-OHdG浓度的室内空气污染因素,包括室外来源的污染物、吸烟、室内燃烧及烹调油烟、室内装修材料中的化学物质、建筑物地基。通过测定人群尿8-OHdG浓度,为推测室内空气污染对人群健康的影响(DNA氧化损伤和相关疾病)提供理论依据。
8-hydroxydeoxyguanosine(8-OHdG)in human urine is a marker reflecting oxidative stress and DNA oxidative damage.People spend 80%-90%of their life indoors;therefore,indoor air quality is directly related to human health.In this paper,the urinary 8-OHdG levels were presented in populations grouped by different demographic characteristics,lifestyle,occupational exposure,and health status,and elucidated indoor pollutants affecting human urinary 8-OHdG level,such as pollutants from outdoor sources,smoking,indoor combustion and cooking fumes,the chemicals in interior decoration materials,and building foundation soils.The article aims to provide a theoretical basis for predicting the impact of indoor air pollution on human health(DNA oxidative damage and related diseases)by measuring the concentration of8-OHdG in human urine.
作者
石金刚
贺淼
SHI Jingang;HE Miao(School of Public Health,China Medical University,Shenyang,Liaoning 110122,China;Liaoning Provincial Key Laboratory of Environmental Health Damage Research and Assessment,China Medical University,Shenyang,Liaoning 110122,China)
出处
《环境与职业医学》
CAS
CSCD
北大核心
2022年第4期465-469,共5页
Journal of Environmental and Occupational Medicine
基金
辽宁省自然科学基金重点项目(20170541038)
