心外膜脂肪组织:心血管病防治的新靶点

Epicardial adipose tissue:new target for prevention and treatment of cardiovascular diseases

心外膜脂肪组织(EAT)增加心脏代谢风险。高血压、糖尿病、肥胖等危险因素促进EAT积聚,EAT产生促炎症脂肪因子,损害冠状动脉微循环血管,引起心房和心室心肌纤维化、冠状动脉钙化,从而引发心血管病。心脏磁共振是目前测量EAT厚度的重要手段。通过测量EAT厚度有助于判断心房颤动、冠心病和心力衰竭等心血管病预后。抑制EAT形成的药物可以降低心房颤动和心力衰竭的发生发展。

Epicardial adipose tissue(EAT)increases the risk of cardiac metabolism.Hypertension,diabetes,obesity and other risk factors contribute to the accumulation of EAT.The pro-inflammatory fat factors secreted from EAT could lead to the damage of coronary microcirculation vessels,myocardial fibrosis,and calcification of coronary artery,which result in cardiovascular disease.At present,myocardial MRI is an important method to measure the thickness of EAT.EAT thickness measurement is helpful for predicting the prognosis of cardiovascular diseases,such as atrial fibrillation,coronary heart disease and heart failure.Drugs that inhibit the formation of EAT could alleviate the development of atrial fibrillation and heart failure.