鼻咽癌患者生活质量评价及影响因素综述

Research advances in evaluation and influencing factors of quality of life in patients with nasopharyngeal carcinoma

鼻咽癌(nasopharyngeal carcinoma,NPC)患者在经过放疗、化疗和(或)靶向等综合治疗后可获得较长的生存时间,随着生存期的延长,患者的生活质量(quality of life,QOL)逐渐成为关注的热点。鼻咽癌患者的生活质量需要通过专业量表进行评价,包括EORTC QLQ-C30、QLQ-H&N35、FACT-G和FACT-H&N等。放疗技术及方案设计、肿瘤分期、化疗方案的选择、患者身体及心理状态、性别、年龄、随访时间、教育层次、经济条件、护理等在不同程度上影响鼻咽癌患者的生活质量。

Nasopharyngeal carcinoma(NPC)patients can achieve a better survival after comprehensive treatments including radiotherapy,chemotherapy and/or targeted treatments.The quality of life(QOL)of patients with long-term survival has become a research hotspot recently.Several well-validated questionnaires including EORTC QLQ-C30 and QLQ-H&N35,FACT-G and FACT-H&N are used for evaluating QOL in NPC patients.Researches show that radiotherapy technology and planning,tumor staging,chemotherapy regimen,physical and psychological condition,gender,age,follow-up time,education level,economic condition,nursing care,etc.will affect the quality of life to some extent.