Hp感染与结直肠息肉及结直肠癌发病风险的相关性

Relationship between Hp infection and risk of colorectal polyps and colorectal cancer

目的分析幽门螺杆菌感染同结直肠息肉、结直肠癌患病风险之间关联性。方法选择在曹县县立医院实施结肠镜检查,并通过病理检查确诊为结直肠息肉的500例病患和初次诊断的100例结直肠癌病患为研究样本,同时将在本院实施结肠镜检查的200例健康体检者作为常规组,其研究时间均在2016年4月至2019年4月之间。全部研究样本均在同期实施胃黏膜活检快速尿素酶检查。采集所有研究样本息肉数量和大小、结直肠癌位置、幽门螺杆菌感染情况。分析常规组中幽门螺杆菌感染情况;分析结直肠息肉病患幽门螺杆菌感染情况;分析结直肠癌病患幽门螺杆菌感染情况。结果常规组健康体检者中,幽门螺杆菌感染出现率是30.00%,其中各年龄段男性幽门螺杆菌感染出现率均高于女性(P<0.05)。结直肠息肉病患中,幽门螺杆菌感染出现率是31.60%;其中息肉<1.0 cm者幽门螺杆菌感染出现率是28.13%,息肉≥1.0 cm者幽门螺杆菌感染出现率是43.10%,息肉≥1.0 cm者幽门螺杆菌感染出现率高于息肉<1.0 cm者(P<0.05);单发息肉病患中,幽门螺杆菌感染出现率是24.79%,在多发息肉病患中,幽门螺杆菌感染出现率是37.98%,多发息肉病患幽门螺杆菌感染出现率高于单发息肉病患(P<0.05)。结直肠癌病患中,幽门螺杆菌感染出现率是36.00%;在左半结肠和直肠组中,幽门螺杆菌感染出现率是37.50%,在右半结肠组中,幽门螺杆菌感染出现率是33.33%,两者比较无明显差异(P>0.05)。结论结直肠息肉病患以及结直肠癌病患幽门螺杆菌感染出现率均高于常规组健康体检者,并且结直肠癌病患幽门螺杆菌感染出现率高于结直肠息肉病患。对于结直肠息肉直径越大、数量越多的病患,其幽门螺杆菌感染出现率越高,而幽门螺杆菌感染出现率同结直肠癌发病部位无明显相关性。

Objective To analyze the relationship between Helicobacter pylori infection and the risk of colorectal polyps and colorectal cancer.Methods Totally 500 patients with colorectal polyps and 100 patients with colorectal cancer diagnosed for the first time by pathological examination and colonoscopy examination in our hospital were selected as the study samples,and 200 healthy people who underwent colonoscopy examination in our hospital were selected as the routine group.The study time was from April 2016 to April 2019.Rapid urease test of gastric mucosa biopsy was performed in all samples.The number and size of polyps,location of colorectal cancer and Helicobacter pylori infection were collected.Helicobacter pylori infection in routine group was analyzed,Helicobacter pylori infection in colorectal polyposis was analyzed,Helicobacter pylori infection in colorectal cancer patients was analyzed.Results In the routine group,the incidence of Helicobacter pylori infection was 30.00%,and the incidence of Helicobacter pylori infection in men was higher than that in women(P<0.05).In patients with colorectal polyps,the incidence of Helicobacter pylori infection was 31.60%;The incidence of Helicobacter pylori infection was 28.13%in patients with polyps<1.0 cm,43.10%in patients with polyps≥1.0 cm,and the incidence of Helicobacter pylori infection in patients with polyps≥1.0 cm was higher than that in patients with polyps<1.0 cm(P<0.05);The incidence of Helicobacter pylori infection was 24.79%in patients with single polyp and 37.98%in patients with multiple polyps.The incidence of Helicobacter pylori infection in patients with multiple polyps was higher than that in patients with single polyp(P<0.05).In colorectal cancer patients,the incidence of Helicobacter pylori infection was 36.00%;in the left colon and rectum group,the incidence of Helicobacter pylori infection was 37.50%,in the right colon group,the incidence of Helicobacter pylori infection was 33.33%,there was no significant difference between the two groups(P>0.05).Conclusion The incidence of Helicobacter pylori infection in patients with colorectal polyps and patients with colorectal cancer is higher than that in the normal group,and the incidence of Helicobacter pylori infection in patients with colorectal cancer is higher than that in patients with colorectal polyps.The larger the diameter of colorectal polyps,the more the number of patients,the higher the incidence of Helicobacter pylori infection.